Analgesics
Antiandrogens
Antihistamines
Azvudine
Bromhexine
Budesonide
Colchicine
Conv. Plasma
Curcumin
Famotidine
Favipiravir
Fluvoxamine
Hydroxychlor..
Ivermectin
Lifestyle
Melatonin
Metformin
Minerals
Molnupiravir
Monoclonals
Naso/orophar..
Nigella Sativa
Nitazoxanide
PPIs
Paxlovid
Quercetin
Remdesivir
Thermotherapy
Vitamins
More

Other
Feedback
Home
Top
Results
Abstract
All HCQ studies
Meta analysis
 
Feedback
Home
next
study
previous
study
c19hcq.org COVID-19 treatment researchHCQHCQ (more..)
Melatonin Meta
Metformin Meta
Antihistamines Meta
Azvudine Meta Molnupiravir Meta
Bromhexine Meta
Budesonide Meta
Colchicine Meta Nigella Sativa Meta
Conv. Plasma Meta Nitazoxanide Meta
Curcumin Meta PPIs Meta
Famotidine Meta Paxlovid Meta
Favipiravir Meta Quercetin Meta
Fluvoxamine Meta Remdesivir Meta
Hydroxychlor.. Meta Thermotherapy Meta
Ivermectin Meta

All Studies   Meta Analysis    Recent:   

A report from the Brescia Renal COVID Task Force on the clinical characteristics and short-term outcome of hemodialysis patients with SARS-CoV-2 infection

Alberici et al., Kidney Int., 98:1, 20-26, July 1, 2020, doi:10.1016/j.kint.2020.04.030 (date from preprint)
May 2020  
  Post
  Facebook
Share
  Source   PDF   All Studies   Meta AnalysisMeta
Mortality 43% Improvement Relative Risk HCQ for COVID-19  Alberici et al.  LATE TREATMENT Is late treatment with HCQ beneficial for COVID-19? Retrospective 94 patients in Italy Lower mortality with HCQ (not stat. sig., p=0.12) c19hcq.org Alberici et al., Kidney Int., 20-26, J.., May 2020 FavorsHCQ Favorscontrol 0 0.5 1 1.5 2+
HCQ for COVID-19
1st treatment shown to reduce risk in March 2020
 
*, now with p < 0.00000000001 from 417 studies, recognized in 46 countries.
No treatment is 100% effective. Protocols combine treatments. * >10% efficacy, ≥3 studies.
4,800+ studies for 98 treatments. c19hcq.org
Analysis of 94 hemodialysis COVID-19 positive patients, showing lower mortality with HCQ treatment, not reaching statistical significance.
risk of death, 42.9% lower, RR 0.57, p = 0.12, treatment 17 of 72 (23.6%), control 9 of 22 (40.9%), NNT 5.8, odds ratio converted to relative risk.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Alberici et al., 10 May 2020, retrospective, Italy, peer-reviewed, 31 authors, average treatment delay 4.0 days.
This PaperHCQAll
A report from the Brescia Renal COVID Task Force on the clinical characteristics and short-term outcome of hemodialysis patients with SARS-CoV-2 infection
Federico Alberici, Elisa Delbarba, Chiara Manenti, Laura Econimo, Francesca Valerio, Alessandra Pola, Camilla Maffei, Stefano Possenti, Bernardo Lucca, Roberta Cortinovis, Vincenzo Terlizzi, Mattia Zappa, Chiara Saccà, Elena Pezzini, Eleonora Calcaterra, Paola Piarulli, Alice Guerini, Francesca Boni, Agnese Gallico, Alberto Mucchetti, Stefania Affatato, Sergio Bove, Martina Bracchi, Ester Maria Costantino, Roberto Zubani, Corrado Camerini, Paola Gaggia, Ezio Movilli, Nicola Bossini, Mario Gaggiotti, Francesco Scolari
Kidney International, doi:10.1016/j.kint.2020.04.030
The SARS-CoV-2 epidemic is pressuring healthcare systems worldwide. Disease outcomes in certain subgroups of patients are still scarce, and data are needed. Therefore, we describe here the experience of four dialysis centers of the Brescia Renal COVID Task Force. During March 2020, within an overall population of 643 hemodialysis patients, SARS-CoV-2 RNA positivity was detected in 94 (15%). At disease diagnosis, 37 of the 94 (39%) patients (group 1) were managed on an outpatient basis, whereas the remaining 57 (61%) (group 2) required hospitalization. Choices regarding management strategy were made based on disease severity. In group 1, 41% received antivirals and 76% hydroxychloroquine. Eight percent died and 5% developed acute respiratory distress syndrome (ARDS). In group 2, 79% received antivirals and 77% hydroxychloroquine. Forty two percent died and 79% developed ARDS. Overall mortality rate for the entire cohort was 29%. History of ischemic cardiac disease, fever, older age (over age 70), and dyspnea at presentation were associated with the risk of developing ARDS, whereas fever, cough and a C-reactive protein higher than 50 mg/l at disease presentation were associated with the risk of death. Thus, in our population of hemodialysis patients with SARS-CoV-2 infection, we documented a wide range of disease severity. The risk of ARDS and death is significant for patients requiring hospital admission at disease diagnosis.
References
Alberici, Delbarba, Manenti, A single center observational study of the clinical characteristics and short-term outcome of 20 kidney transplant patients admitted for SARS-CoV2 pneumonia, Kidney Int
Alberici, Delbarba, Manenti, Management of patients on dialysis and with kidney transplantation during the SARS-CoV-2 (COVID-19) pandemic in Brescia, Italy, Kidney Int Rep
Banerjee, Popoola, Shah, COVID-19 infection in kidney transplant recipients, Kidney Int
Burgner, Ikizler, Dwyer, COVID-19 and the inpatient dialysis unit: managing resources during contingency planning pre-crisis, Clin J Am Soc Nephrol
Force, Ranieri, Rubenfeld, Acute respiratory distress syndrome: the Berlin Definition, JAMA
Henry, Lippi, Chronic kidney disease is associated with severe coronavirus disease 2019 (COVID-19) infection
Huang, Wang, Li, Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China, Lancet
Mcmichael, Currie, Clark, Epidemiology of Covid-19 in a long-term care facility in King County, Washington, N Engl J Med
Onder, Rezza, Brusaferro, Case-fatality rate and characteristics of patients dying in relation to COVID-19 in Italy
Wang, Liao, He, COVID-19 in hemodialysis patients: a report of 5 cases
Wu, Chen, Cai, Risk factors associated with acute respiratory distress syndrome and death in patients with Coronavirus disease 2019 pneumonia in Wuhan, China
Wu, Mcgoogan, Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in China: summary of a report of 72314 cases from the Chinese Center for Disease Control and Prevention, JAMA
Yancy, Jessup, Bozkurt, ACCF/AHA guideline for the management of heart failure: a report of the American College of Cardiology Foundation/ American Heart Association Task Force on Practice Guidelines, J Am Coll Cardiol
Yang, Yu, Xu, Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study, Lancet Respir Med
{ 'indexed': {'date-parts': [[2024, 4, 6]], 'date-time': '2024-04-06T11:56:41Z', 'timestamp': 1712404601079}, 'reference-count': 15, 'publisher': 'Elsevier BV', 'issue': '1', 'license': [ { 'start': { 'date-parts': [[2020, 7, 1]], 'date-time': '2020-07-01T00:00:00Z', 'timestamp': 1593561600000}, 'content-version': 'tdm', 'delay-in-days': 0, 'URL': 'https://www.elsevier.com/tdm/userlicense/1.0/'}], 'content-domain': { 'domain': ['kidney-international.org', 'elsevier.com', 'sciencedirect.com'], 'crossmark-restriction': True}, 'published-print': {'date-parts': [[2020, 7]]}, 'DOI': '10.1016/j.kint.2020.04.030', 'type': 'journal-article', 'created': {'date-parts': [[2020, 5, 8]], 'date-time': '2020-05-08T07:09:27Z', 'timestamp': 1588921767000}, 'page': '20-26', 'update-policy': 'http://dx.doi.org/10.1016/elsevier_cm_policy', 'source': 'Crossref', 'is-referenced-by-count': 168, 'title': 'A report from the Brescia Renal COVID Task Force on the clinical characteristics and\xa0' 'short-term outcome of hemodialysis patients\xa0with\xa0SARS-CoV-2 infection', 'prefix': '10.1016', 'volume': '98', 'author': [ {'given': 'Federico', 'family': 'Alberici', 'sequence': 'first', 'affiliation': []}, {'given': 'Elisa', 'family': 'Delbarba', 'sequence': 'additional', 'affiliation': []}, {'given': 'Chiara', 'family': 'Manenti', 'sequence': 'additional', 'affiliation': []}, {'given': 'Laura', 'family': 'Econimo', 'sequence': 'additional', 'affiliation': []}, {'given': 'Francesca', 'family': 'Valerio', 'sequence': 'additional', 'affiliation': []}, {'given': 'Alessandra', 'family': 'Pola', 'sequence': 'additional', 'affiliation': []}, {'given': 'Camilla', 'family': 'Maffei', 'sequence': 'additional', 'affiliation': []}, {'given': 'Stefano', 'family': 'Possenti', 'sequence': 'additional', 'affiliation': []}, {'given': 'Bernardo', 'family': 'Lucca', 'sequence': 'additional', 'affiliation': []}, {'given': 'Roberta', 'family': 'Cortinovis', 'sequence': 'additional', 'affiliation': []}, {'given': 'Vincenzo', 'family': 'Terlizzi', 'sequence': 'additional', 'affiliation': []}, {'given': 'Mattia', 'family': 'Zappa', 'sequence': 'additional', 'affiliation': []}, {'given': 'Chiara', 'family': 'Saccà', 'sequence': 'additional', 'affiliation': []}, {'given': 'Elena', 'family': 'Pezzini', 'sequence': 'additional', 'affiliation': []}, {'given': 'Eleonora', 'family': 'Calcaterra', 'sequence': 'additional', 'affiliation': []}, {'given': 'Paola', 'family': 'Piarulli', 'sequence': 'additional', 'affiliation': []}, {'given': 'Alice', 'family': 'Guerini', 'sequence': 'additional', 'affiliation': []}, {'given': 'Francesca', 'family': 'Boni', 'sequence': 'additional', 'affiliation': []}, {'given': 'Agnese', 'family': 'Gallico', 'sequence': 'additional', 'affiliation': []}, {'given': 'Alberto', 'family': 'Mucchetti', 'sequence': 'additional', 'affiliation': []}, {'given': 'Stefania', 'family': 'Affatato', 'sequence': 'additional', 'affiliation': []}, {'given': 'Sergio', 'family': 'Bove', 'sequence': 'additional', 'affiliation': []}, {'given': 'Martina', 'family': 'Bracchi', 'sequence': 'additional', 'affiliation': []}, {'given': 'Ester Maria', 'family': 'Costantino', 'sequence': 'additional', 'affiliation': []}, {'given': 'Roberto', 'family': 'Zubani', 'sequence': 'additional', 'affiliation': []}, {'given': 'Corrado', 'family': 'Camerini', 'sequence': 'additional', 'affiliation': []}, {'given': 'Paola', 'family': 'Gaggia', 'sequence': 'additional', 'affiliation': []}, {'given': 'Ezio', 'family': 'Movilli', 'sequence': 'additional', 'affiliation': []}, {'given': 'Nicola', 'family': 'Bossini', 'sequence': 'additional', 'affiliation': []}, {'given': 'Mario', 'family': 'Gaggiotti', 'sequence': 'additional', 'affiliation': []}, {'given': 'Francesco', 'family': 'Scolari', 'sequence': 'additional', 'affiliation': []}], 'member': '78', 'reference': [ { 'key': '10.1016/j.kint.2020.04.030_bib1', 'doi-asserted-by': 'crossref', 'first-page': '580', 'DOI': '10.1016/j.ekir.2020.04.001', 'article-title': 'Management of patients on dialysis and with kidney transplantation ' 'during the SARS-CoV-2 (COVID-19) pandemic in Brescia, Italy', 'volume': '5', 'author': 'Alberici', 'year': '2020', 'journal-title': 'Kidney Int Rep'}, { 'key': '10.1016/j.kint.2020.04.030_bib2', 'doi-asserted-by': 'crossref', 'unstructured': 'Henry BM, Lippi G. Chronic kidney disease is associated with severe ' 'coronavirus disease 2019 (COVID-19) infection [e-pub ahead of print]. ' 'Int Urol Nephrol. https://doi.org/10.1007/s11255-020-02451-9. Accessed ' 'April 13, 2020.', 'DOI': '10.1007/s11255-020-02451-9'}, { 'key': '10.1016/j.kint.2020.04.030_bib3', 'doi-asserted-by': 'crossref', 'unstructured': 'Wang R, Liao C, He H, et\xa0al. COVID-19 in hemodialysis patients: a ' 'report of 5 cases [e-pub ahead of print]. Am J Kidney Dis. ' 'https://doi.org/10.1053/j.ajkd.2020.03.009. Accessed April 12, 2020.', 'DOI': '10.1053/j.ajkd.2020.03.009'}, { 'key': '10.1016/j.kint.2020.04.030_bib4', 'doi-asserted-by': 'crossref', 'first-page': '720', 'DOI': '10.2215/CJN.03750320', 'article-title': 'COVID-19 and the inpatient dialysis unit: managing resources during ' 'contingency planning pre-crisis', 'volume': '15', 'author': 'Burgner', 'year': '2020', 'journal-title': 'Clin J Am Soc Nephrol.'}, { 'key': '10.1016/j.kint.2020.04.030_bib5', 'series-title': 'The Epidemiological Characteristics of an Outbreak of 2019 Novel ' 'Coronavirus Disease (COVID-19)—China', 'year': '2020'}, { 'key': '10.1016/j.kint.2020.04.030_bib6', 'doi-asserted-by': 'crossref', 'first-page': '497', 'DOI': '10.1016/S0140-6736(20)30183-5', 'article-title': 'Clinical features of patients infected with 2019 novel coronavirus in ' 'Wuhan, China', 'volume': '395', 'author': 'Huang', 'year': '2020', 'journal-title': 'Lancet'}, { 'key': '10.1016/j.kint.2020.04.030_bib7', 'doi-asserted-by': 'crossref', 'first-page': '1083', 'DOI': '10.1016/j.kint.2020.04.002', 'article-title': 'A\xa0single center observational study of the clinical characteristics ' 'and short-term outcome of 20 kidney transplant patients admitted for ' 'SARS-CoV2 pneumonia', 'volume': '5', 'author': 'Alberici', 'year': '2020', 'journal-title': 'Kidney Int'}, { 'key': '10.1016/j.kint.2020.04.030_bib8', 'doi-asserted-by': 'crossref', 'first-page': '1076', 'DOI': '10.1016/j.kint.2020.03.018', 'article-title': 'COVID-19 infection in kidney transplant recipients', 'volume': '5', 'author': 'Banerjee', 'year': '2020', 'journal-title': 'Kidney Int'}, { 'key': '10.1016/j.kint.2020.04.030_bib9', 'doi-asserted-by': 'crossref', 'first-page': '1239', 'DOI': '10.1001/jama.2020.2648', 'article-title': 'Characteristics of and important lessons from the coronavirus disease ' '2019 (COVID-19) outbreak in China: summary of a report of 72314 cases ' 'from the Chinese Center for Disease Control and Prevention', 'volume': '323', 'author': 'Wu', 'year': '2020', 'journal-title': 'JAMA'}, { 'key': '10.1016/j.kint.2020.04.030_bib10', 'doi-asserted-by': 'crossref', 'unstructured': 'Onder G, Rezza G, Brusaferro S. Case-fatality rate and characteristics ' 'of patients dying in relation to COVID-19 in Italy [e-pub ahead of ' 'print]. JAMA. https://doi.org/10.1001/jama.2020.4683. Accessed April 14, ' '2020.', 'DOI': '10.1001/jama.2020.4683'}, { 'key': '10.1016/j.kint.2020.04.030_bib11', 'doi-asserted-by': 'crossref', 'unstructured': 'Wu C, Chen X, Cai Y, et\xa0al. Risk factors associated with acute ' 'respiratory distress syndrome and death in patients with Coronavirus ' 'disease 2019 pneumonia in Wuhan, China [e-pub ahead of print]. JAMA ' 'Intern Med. https://doi.org/10.1001/jamainternmed.2020.0994. Accessed ' 'April 14, 2020.', 'DOI': '10.1001/jamainternmed.2020.0994'}, { 'key': '10.1016/j.kint.2020.04.030_bib12', 'doi-asserted-by': 'crossref', 'first-page': '475', 'DOI': '10.1016/S2213-2600(20)30079-5', 'article-title': 'Clinical course and outcomes of critically ill patients with SARS-CoV-2 ' 'pneumonia in Wuhan, China: a single-centered, retrospective, ' 'observational study', 'volume': '8', 'author': 'Yang', 'year': '2020', 'journal-title': 'Lancet Respir Med'}, { 'key': '10.1016/j.kint.2020.04.030_bib13', 'first-page': '2526', 'article-title': 'Acute respiratory distress syndrome: the Berlin Definition', 'volume': '307', 'author': 'Force', 'year': '2012', 'journal-title': 'JAMA'}, { 'key': '10.1016/j.kint.2020.04.030_bib14', 'doi-asserted-by': 'crossref', 'first-page': 'e147', 'DOI': '10.1016/j.jacc.2013.05.019', 'article-title': '2013 ACCF/AHA guideline for the management of heart failure: a report ' 'of the American College of Cardiology Foundation/American Heart ' 'Association Task Force on Practice Guidelines', 'volume': '62', 'author': 'Yancy', 'year': '2013', 'journal-title': 'J\xa0Am Coll Cardiol'}, { 'key': '10.1016/j.kint.2020.04.030_bib15', 'doi-asserted-by': 'crossref', 'first-page': '2005', 'DOI': '10.1056/NEJMoa2005412', 'article-title': 'Epidemiology of Covid-19 in a long-term care facility in King County, ' 'Washington', 'volume': '382', 'author': 'McMichael', 'year': '2020', 'journal-title': 'N Engl J Med'}], 'container-title': 'Kidney International', 'original-title': [], 'language': 'en', 'link': [ { 'URL': 'https://api.elsevier.com/content/article/PII:S0085253820305081?httpAccept=text/xml', 'content-type': 'text/xml', 'content-version': 'vor', 'intended-application': 'text-mining'}, { 'URL': 'https://api.elsevier.com/content/article/PII:S0085253820305081?httpAccept=text/plain', 'content-type': 'text/plain', 'content-version': 'vor', 'intended-application': 'text-mining'}], 'deposited': { 'date-parts': [[2020, 6, 19]], 'date-time': '2020-06-19T09:11:30Z', 'timestamp': 1592557890000}, 'score': 1, 'resource': {'primary': {'URL': 'https://linkinghub.elsevier.com/retrieve/pii/S0085253820305081'}}, 'subtitle': [], 'short-title': [], 'issued': {'date-parts': [[2020, 7]]}, 'references-count': 15, 'journal-issue': {'issue': '1', 'published-print': {'date-parts': [[2020, 7]]}}, 'alternative-id': ['S0085253820305081'], 'URL': 'http://dx.doi.org/10.1016/j.kint.2020.04.030', 'relation': {}, 'ISSN': ['0085-2538'], 'subject': ['Nephrology'], 'container-title-short': 'Kidney International', 'published': {'date-parts': [[2020, 7]]}, 'assertion': [ {'value': 'Elsevier', 'name': 'publisher', 'label': 'This article is maintained by'}, { 'value': 'A report from the Brescia Renal COVID Task Force on the clinical ' 'characteristics and\xa0short-term outcome of hemodialysis patients\xa0with\xa0' 'SARS-CoV-2 infection', 'name': 'articletitle', 'label': 'Article Title'}, {'value': 'Kidney International', 'name': 'journaltitle', 'label': 'Journal Title'}, { 'value': 'https://doi.org/10.1016/j.kint.2020.04.030', 'name': 'articlelink', 'label': 'CrossRef DOI link to publisher maintained version'}, { 'value': 'https://doi.org/10.1016/j.kint.2020.04.021', 'name': 'associatedlink', 'label': 'CrossRef DOI link to the associated document'}, { 'value': 'https://doi.org/10.1016/j.kint.2020.04.032', 'name': 'associatedlink', 'label': 'CrossRef DOI link to the associated document'}, { 'value': 'https://doi.org/10.1016/j.kint.2020.04.031', 'name': 'associatedlink', 'label': 'CrossRef DOI link to the associated document'}, {'value': 'simple-article', 'name': 'content_type', 'label': 'Content Type'}, { 'value': '© 2020 International Society of Nephrology. Published by Elsevier Inc. All ' 'rights reserved.', 'name': 'copyright', 'label': 'Copyright'}]}
Late treatment
is less effective
Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
  or use drag and drop   
Submit