Mortality and associated prognostic factors in elderly and very elderly hospitalized patients with respiratory disease COVID-19

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Marzo 2020.'}, { 'key': '10.1016/j.regg.2020.09.006_bib0205', 'doi-asserted-by': 'crossref', 'first-page': '497', 'DOI': '10.1016/S0140-6736(20)30183-5', 'article-title': 'Clinical features of patients infected with 2019 novel coronavirus in ' 'Wuhan, China', 'volume': '395', 'author': 'Huang', 'year': '2020', 'journal-title': 'Lancet (London, England).'}, { 'key': '10.1016/j.regg.2020.09.006_bib0210', 'doi-asserted-by': 'crossref', 'first-page': '1239', 'DOI': '10.1001/jama.2020.2648', 'article-title': 'Characteristics of and important lessons from the coronavirus disease ' '2019 (COVID-19) outbreak in China: Summary of a report of 72?314 cases ' 'from the Chinese Center for Disease Control and Prevention', 'volume': '323', 'author': 'Wu', 'year': '2020', 'journal-title': 'JAMA.'}, { 'key': '10.1016/j.regg.2020.09.006_bib0215', 'doi-asserted-by': 'crossref', 'first-page': '1061', 'DOI': '10.1001/jama.2020.1585', 'article-title': 'Clinical characteristics of 138 hospitalized patients with 2019 novel ' 'coronavirus-infected pneumonia in Wuhan, China', 'volume': '323', 'author': 'Wang', 'year': '2020', 'journal-title': 'JAMA.'}, { 'key': '10.1016/j.regg.2020.09.006_bib0220', 'doi-asserted-by': 'crossref', 'first-page': 'e54', 'DOI': '10.1016/S2213-2600(20)30116-8', 'article-title': 'Are patients with hypertension and diabetes mellitus at increased risk ' 'for COVID-19 infection?', 'volume': '8', 'author': 'Fang', 'year': '2020', 'journal-title': 'Lancet Respir Med.'}, { 'key': '10.1016/j.regg.2020.09.006_bib0225', 'doi-asserted-by': 'crossref', 'first-page': '475', 'DOI': '10.1016/S2213-2600(20)30079-5', 'article-title': 'Clinical course and outcomes of critically ill patients with SARS-CoV-2 ' 'pneumonia in Wuhan, China: A single-centered, retrospective, ' 'observational study', 'volume': '8', 'author': 'Yang', 'year': '2020', 'journal-title': 'Lancet Respir Med.'}, { 'key': '10.1016/j.regg.2020.09.006_bib0230', 'doi-asserted-by': 'crossref', 'first-page': '3085', 'DOI': '10.1016/j.jacc.2020.04.028', 'article-title': 'Clinical implications of SARS-CoV-2 interaction with renin angiotensin ' 'system: JACC Review Topic of the Week', 'volume': '75', 'author': 'Brojakowska', 'year': '2020', 'journal-title': 'J Am Coll Cardiol.'}, { 'key': '10.1016/j.regg.2020.09.006_bib0235', 'doi-asserted-by': 'crossref', 'first-page': '781', 'DOI': '10.1097/HJH.0000000000002450', 'article-title': 'Can angiotensin receptor-blocking drugs perhaps be harmful in the ' 'COVID-19 pandemic?', 'volume': '38', 'author': 'Esler', 'year': '2020', 'journal-title': 'J Hypertens.'}, { 'key': '10.1016/j.regg.2020.09.006_bib0240', 'doi-asserted-by': 'crossref', 'unstructured': 'Sommerstein R, Gräni C. Preventing a COVID-19 pandemic: ACE inhibitors ' 'as a potential risk factor for fatal COVID-19. BMJ. 2020; 368:m810-m810. ' '[Internet] [acceso 26 Jun 2020]. Disponible en: ' 'https://www.bmj.com/content/368/bmj.m810/rr-2/', 'DOI': '10.1136/bmj.m810'}, { 'key': '10.1016/j.regg.2020.09.006_bib0245', 'doi-asserted-by': 'crossref', 'first-page': '1671', 'DOI': '10.1161/CIRCRESAHA.120.317134', 'article-title': 'Association of inpatient use of angiotensin-converting enzyme ' 'inhibitors and angiotensin ii receptor blockers with mortality among ' 'patients with hypertension hospitalized with COVID-19', 'volume': '126', 'author': 'Zhang', 'year': '2020', 'journal-title': 'Circ Res.'}, { 'key': '10.1016/j.regg.2020.09.006_bib0250', 'doi-asserted-by': 'crossref', 'first-page': '1653', 'DOI': '10.1056/NEJMsr2005760', 'article-title': 'Renin-angiotensin-aldosterone system inhibitors in patients with ' 'Covid-19', 'volume': '382', 'author': 'Vaduganathan', 'year': '2020', 'journal-title': 'N Engl J Med.'}, { 'key': '10.1016/j.regg.2020.09.006_bib0255', 'doi-asserted-by': 'crossref', 'first-page': '2058', 'DOI': '10.1093/eurheartj/ehaa433', 'article-title': 'Association of hypertension and antihypertensive treatment with ' 'COVID-19 mortality: A retrospective observational study', 'volume': '41', 'author': 'Gao', 'year': '2020', 'journal-title': 'Eur Heart J.'}, { 'key': '10.1016/j.regg.2020.09.006_bib0260', 'unstructured': 'Position Statement of the ESC Council on Hypertension on ACE-Inhibitors ' 'and Angiotensin Receptor Blockers [nota de prensa]. Marzo 2020.'}, { 'key': '10.1016/j.regg.2020.09.006_bib0265', 'unstructured': 'A statement from the International Society of Hypertension on COVID-19. ' '[nota de prensa]. Marzo 2020.'}, { 'key': '10.1016/j.regg.2020.09.006_bib0270', 'unstructured': 'Instituto Nacional de Estadística. Cifras de población y censos ' 'demográficos. [Internet] [acceso 25 Jun 2020] Disponible en: ' 'https://www.ine.es/dyngs/INEbase/es/categoria.htm?c=Estadistica_P&cid=1254735572981/'}, { 'key': '10.1016/j.regg.2020.09.006_bib0275', 'unstructured': 'Situación de COVID-19 en España. Ministerio de Sanidad [Internet] ' '[acceso 24 Jun 2020] Disponible en: https://covid19.isciii.es/.'}, { 'key': '10.1016/j.regg.2020.09.006_bib0280', 'unstructured': 'United Nations, Department of Economic and Social Affairs, Population ' 'Division World Population Ageing 2019: Highlights (ST/ESA/SER.A/430). ' '[Internet] [acceso 26 Jun 2020]. Disponible en: ' 'https://www.un.org/en/development/desa/population/publications/pdf/ageing/WorldPopulationAgeing2019-Highlights.pdf/'}, { 'key': '10.1016/j.regg.2020.09.006_bib0285', 'doi-asserted-by': 'crossref', 'first-page': '569', 'DOI': '10.1016/j.recesp.2020.03.027', 'article-title': 'Coronavirus: the geriatric emergency of 2020. Joint document of the ' 'Section on Geriatric Cardiology of the Spanish Society of Cardiology ' 'and the Spanish Society of Geriatrics and Gerontology', 'volume': '73', 'author': 'Bonanad', 'year': '2020', 'journal-title': 'Rev Esp Cardiol (Engl Ed).'}, { 'key': '10.1016/j.regg.2020.09.006_bib0290', 'doi-asserted-by': 'crossref', 'first-page': '125', 'DOI': '10.3855/jidc.12600', 'article-title': 'Similarity in Case Fatality Rates (CFR) of COVID-19/SARS-COV-2 in Italy ' 'and China', 'volume': '14', 'author': 'Porcheddu', 'year': '2020', 'journal-title': 'J Infect Dev Ctries.'}, { 'key': '10.1016/j.regg.2020.09.006_bib0295', 'unstructured': 'European Geriatric Medicine. Statement of the EuGMS Executive Board on ' 'the COVID-19 epidemic. [Internet] [acceso 25 Jun 2020] Disponible en:\xa0' 'https://www.eugms.org/news/read/article/489.html'}, { 'key': '10.1016/j.regg.2020.09.006_bib0300', 'unstructured': 'Informe del Ministerio de Sanidad sobre los aspectos éticos en ' 'situaciones de pandemia: El SARS-CoV-2 02.04.2020 [Internet] [acceso 15 ' 'Ago 2020]. Disponible en https://www.iscii.es/'}, { 'key': '10.1016/j.regg.2020.09.006_bib0305', 'doi-asserted-by': 'crossref', 'first-page': '217', 'DOI': '10.1097/JCMA.0000000000000270', 'article-title': 'The outbreak of COVID-19: An overview', 'volume': '83', 'author': 'Wu', 'year': '2020', 'journal-title': 'J Chin Med Assoc.'}, { 'key': '10.1016/j.regg.2020.09.006_bib0310', 'doi-asserted-by': 'crossref', 'first-page': '104058', 'DOI': '10.1016/j.archger.2020.104058', 'article-title': 'Clinical characteristics of older patients infected with COVID-19: A ' 'descriptive study', 'volume': '89', 'author': 'Niu', 'year': '2020', 'journal-title': 'Arch Gerontol Geriatr.'}, { 'key': '10.1016/j.regg.2020.09.006_bib0315', 'unstructured': 'Red Nacional de Vigilancia Epidemiológica. Análisis de los casos de ' 'COVID-19 notificados a la RENAVE hasta el 10 de mayo en España: informe ' '33 [Internet] [acceso 27 Jun 2020]. Disponible en: ' 'https://www.isciii.es/'}, { 'key': '10.1016/j.regg.2020.09.006_bib0320', 'doi-asserted-by': 'crossref', 'first-page': '152', 'DOI': '10.3389/fpubh.2020.00152', 'article-title': 'Gender differences in patients with COVID-19: Focus on severity and ' 'mortality', 'volume': '8', 'author': 'Jin', 'year': '2020', 'journal-title': 'Front Public Health.'}, { 'key': '10.1016/j.regg.2020.09.006_bib0325', 'doi-asserted-by': 'crossref', 'first-page': '111255', 'DOI': '10.1016/j.mad.2020.111255', 'article-title': 'Risk factors for predicting mortality in elderly patients with ' 'COVID-19: A review of clinical data in China', 'volume': '188', 'author': 'Leung', 'year': '2020', 'journal-title': 'Mech Ageing Dev.'}, { 'key': '10.1016/j.regg.2020.09.006_bib0330', 'doi-asserted-by': 'crossref', 'first-page': '704', 'DOI': '10.1111/ggi.13960', 'article-title': 'Clinical characteristics and prognostic factors in COVID-19 patients ' 'aged≥80 years', 'volume': '20', 'author': 'Covino', 'year': '2020', 'journal-title': 'Geriatr Gerontol Int.'}, { 'key': '10.1016/j.regg.2020.09.006_bib0335', 'doi-asserted-by': 'crossref', 'first-page': '829', 'DOI': '10.1016/j.kint.2020.03.005', 'article-title': 'Kidney disease is associated with in-hospital death of patients with ' 'COVID-19', 'volume': '97', 'author': 'Cheng', 'year': '2020', 'journal-title': 'Kidney Int.'}, { 'key': '10.1016/j.regg.2020.09.006_bib0340', 'doi-asserted-by': 'crossref', 'first-page': 'e14', 'DOI': '10.1016/j.jinf.2020.03.005', 'article-title': 'Clinical features of COVID-19 in elderly patients: A comparison with ' 'young and middle-aged patients', 'volume': '80', 'author': 'Liu', 'year': '2020', 'journal-title': 'J Infect.'}, { 'key': '10.1016/j.regg.2020.09.006_bib0345', 'doi-asserted-by': 'crossref', 'first-page': '1730', 'DOI': '10.1111/all.14238', 'article-title': 'Clinical characteristics of 140 patients infected with SARS-CoV-2 in ' 'Wuhan, China', 'volume': '75', 'author': 'Zhang', 'year': '2020', 'journal-title': 'Allergy.'}, { 'key': '10.1016/j.regg.2020.09.006_bib0350', 'doi-asserted-by': 'crossref', 'first-page': '639', 'DOI': '10.1016/j.jinf.2020.03.019', 'article-title': 'Coronavirus disease 2019 in elderly patients: Characteristics and ' 'prognostic factors based on 4-week follow-up', 'volume': '80', 'author': 'Wang', 'year': '2020', 'journal-title': 'J Infect.'}, { 'key': '10.1016/j.regg.2020.09.006_bib0355', 'doi-asserted-by': 'crossref', 'first-page': '2145', 'DOI': '10.1021/acschemneuro.0c00391', 'article-title': 'Calcium channel blockers: A possible potential therapeutic strategy for ' "the treatment of Alzheimer's dementia patients with SARS-CoV-2 " 'infection', 'volume': '11', 'author': 'Danta', 'year': '2020', 'journal-title': 'ACS Chem Neurosci.'}, { 'key': '10.1016/j.regg.2020.09.006_bib0360', 'article-title': 'Calcium channel blocker amlodipine besylate is associated with reduced ' 'case fatality rate of COVID-19 patients with hypertension', 'volume': '1', 'author': 'Zhang', 'year': '2020', 'journal-title': 'medRxiv [Internet].'}, { 'key': '10.1016/j.regg.2020.09.006_bib0365', 'first-page': 'e8069', 'article-title': 'Nifedipine and amlodipine are associated with improved mortality and ' 'decreased risk for intubation and mechanical ventilation in elderly ' 'patients hospitalized for COVID-19', 'volume': '12', 'author': 'Solaimanzadeh', 'year': '2020', 'journal-title': 'Cureus.'}, { 'key': '10.1016/j.regg.2020.09.006_bib0370', 'doi-asserted-by': 'crossref', 'DOI': '10.1016/j.rce.2020.07.003', 'article-title': 'Clinical characteristics of patients hospitalized with COVID-19 in ' 'Spain: Results from the SEMI-COVID-19 Registry', 'author': 'Casas-Rojo', 'year': '2020', 'journal-title': 'Rev Clin Esp (Barc).'}, { 'key': '10.1016/j.regg.2020.09.006_bib0375', 'doi-asserted-by': 'crossref', 'first-page': '122', 'DOI': '10.1016/j.jacc.2020.05.001', 'article-title': 'Association of treatment dose anticoagulation with in-hospital survival ' 'among hospitalized patients with COVID-19', 'volume': '76', 'author': 'Paranjpe', 'year': '2020', 'journal-title': 'J Am Coll Cardiol.'}, { 'key': '10.1016/j.regg.2020.09.006_bib0380', 'doi-asserted-by': 'crossref', 'first-page': '844', 'DOI': '10.1111/jth.14768', 'article-title': 'Abnormal coagulation parameters are associated with poor prognosis in ' 'patients with novel coronavirus pneumonia', 'volume': '18', 'author': 'Tang', 'year': '2020', 'journal-title': 'J Thromb Haemost.'}, { 'key': '10.1016/j.regg.2020.09.006_bib0385', 'article-title': 'Anticoagulation, mortality, bleeding and pathology among patients ' 'hospitalized with COVID-19: A single health system study', 'volume': '26', 'author': 'Nadkarni', 'year': '2020', 'journal-title': 'J Am Coll Cardiol [Internet].'}, { 'key': '10.1016/j.regg.2020.09.006_bib0390', 'doi-asserted-by': 'crossref', 'first-page': 'e444', 'DOI': '10.1016/S2468-2667(20)30146-8', 'article-title': 'The effect of frailty on survival in patients with 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