Prediction of mortality in hospitalized Egyptian patients with Coronavirus disease-2019: A multicenter retrospective study

DOI record: { "DOI": "10.1371/journal.pone.0262348", "ISSN": [ "1932-6203" ], "URL": "http://dx.doi.org/10.1371/journal.pone.0262348", "abstract": "<jats:p>We aimed to assess the epidemiological, clinical, and laboratory characteristics associated with mortality among hospitalized Egyptian patients with COVID-19. A multicenter, retrospective study was conducted on all polymerase chain reaction (PCR)-confirmed COVID-19 cases admitted through the period from April to July 2020. A generalized linear model was reconstructed with covariates based on predictor’s statistical significance and clinically relevance. The odds ratio (OR) was calculated by using stepwise logistic regression modeling. A total of 3712 hospitalized patients were included; of them, 900 deaths were recorded (24.2%). Compared to survived patients, non-survived patients were more likely to be older than 60 years (65.7%), males (53.6%) diabetic (37.6%), hypertensive (37.2%), and had chronic renal insufficiency (9%). Non-survived patients were less likely to receive azithromycin (p &lt;0.001), anticoagulants (p &lt;0.001), and steroids (p &lt;0.001). We found that age ≥ 60 years old (OR = 2.82, 95% CI 2.05–3.86; p &lt;0.0001), diabetes mellitus (OR = 1.58, 95% CI 1.14–2.19; p = 0.006), hypertension (OR = 1.69, 95% CI 1.22–2.36; p = 0.002), chronic renal insufficiency (OR = 3.15, 95% CI 1.84–5.38; p &lt;0.0001), tachycardia (OR = 1.65, 95% CI 1.22–2.23; p &lt;0.001), hypoxemia (OR = 5.69, 95% CI 4.05–7.98; p &lt;0.0001), GCS &lt;13 (OR 515.2, 95% CI 148.5–1786.9; p &lt;0.0001), the use of therapeutic dose of anticoagulation (OR = 0.4, 95% CI 0.22–0.74, p = 0.003) and azithromycin (OR = 0.16, 95% CI 0.09–0.26; p &lt;0.0001) were independent negative predictors of mortality. In conclusion, age &gt;60 years, comorbidities, tachycardia, hypoxemia, and altered consciousness level are independent predictors of mortality among Egyptian hospitalized patients with COVID-19. On the other hand, the use of anticoagulants and azithromycin is associated with reduced mortality.</jats:p>", "author": [ { "affiliation": [], "family": "AbdelGhaffar", "given": "Muhammad M.", "sequence": "first" }, { "ORCID": "http://orcid.org/0000-0002-5513-6955", "affiliation": [], "authenticated-orcid": true, "family": "Omran", "given": "Dalia", "sequence": "additional" }, { "affiliation": [], "family": "Elgebaly", "given": "Ahmed", "sequence": "additional" }, { "affiliation": [], "family": "Bahbah", "given": "Eshak I.", "sequence": "additional" }, { "affiliation": [], "family": "Afify", "given": "Shimaa", "sequence": "additional" }, { "affiliation": [], "family": "AlSoda", "given": "Mohamed", "sequence": "additional" }, { "affiliation": [], "family": "El-Shiekh", "given": "Mohamed", "sequence": "additional" }, { "affiliation": [], "family": "ElSayed", "given": "Enass S.", "sequence": "additional" }, { "affiliation": [], "family": "Shaaban", "given": "Soha S.", "sequence": "additional" }, { "affiliation": [], "family": "AbdelHafez", "given": "Samah", "sequence": "additional" }, { "affiliation": [], "family": "Elkelany", "given": "Khaled", "sequence": "additional" }, { "affiliation": [], "family": "Eltayar", "given": "Ayman A.", "sequence": "additional" }, { "affiliation": [], "family": "Ali", "given": "Omnia S.", "sequence": "additional" }, { "affiliation": [], "family": "Kamal", "given": "Lamiaa", "sequence": "additional" }, { "affiliation": [], "family": "Heiba", "given": "Ahmed M.", "sequence": "additional" }, { "affiliation": [], "family": "El Askary", "given": "Ahmad", "sequence": "additional" }, { "ORCID": "http://orcid.org/0000-0002-0928-4738", "affiliation": [], "authenticated-orcid": true, "family": "Shousha", "given": "Hend Ibrahim", "sequence": "additional" } ], "container-title": [ "PLOS ONE" ], "content-domain": { "crossmark-restriction": false, "domain": [ "www.plosone.org" ] }, "created": { "date-parts": [ [ 2022, 1, 11 ] ], "date-time": 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