Assessment of COVID-19 Treatment containing both Hydroxychloroquine and Azithromycin: A Natural Clinical Trial
Abbas et al.
, Assessment of COVID-19 Treatment containing both Hydroxychloroquine and Azithromycin: A Natural Clinical Trial
, Int. J. Clin. Pract., doi:10.1111/ijcp.13856
Prospective study of 161 hospitalized patients in Iraq showing HCQ+AZ appears to help recovery. Most mortality was in patients that were already in critical condition on admission and died before treatment could be effective.
Abbas et al., 24 Nov 2020, prospective, Iraq, peer-reviewed, 8 authors.
Abstract: Received: 25 June 2020
Accepted: 18 November 2020
ORIG INAL PAPER
Assessment of COVID-19 Treatment containing both
Hydroxychloroquine and Azithromycin: A natural clinical trial
Hassan M. Abbas1 | Ali Azeez Al-Jumaili2,3
| Kawthar F. Nassir4
Muhammed Waheeb Al-Obaidy | Adnan Mohammed Al Jubouri
Basim Dhawi Dakhil | Mohammed Mahir Abdulelah | Qutaiba Ahmed Al Khames9
Headquarter, Ministry of Health, Baghdad,
The goal of this study was to assess the clinical effectiveness and safety profile of
College of Pharmacy, University of Iowa,
Iowa City, IA, USA
Clinical Pharmacy Department, University
of Baghdad College of Pharmacy, Baghdad,
the COVID-19 treatment protocol (containing both hydroxychloroquine (HCQ) and
azithromycin) in an Iraqi specialised hospital.
Methods: This prospective study used a pre- and post-intervention design without a
Therapeutic Drug Monitoring Center,
Baghdad Teaching Hospital, Medical City
Complex, Baghdad, Iraq
comparison group. The intervention was routine Ministry of Health (MOH) approved
healthcare setting in Baghdad, Iraq from March 1st to May 25, 2020. The study out-
University of Baghdad College of Medicine,
Baghdad Teaching Hospital, Medical City
Teaching Complex, Baghdad, Iraq
Critical Care Unit, Bagdad Teaching
Hospital, Medical City Complex, Internal
Medicine Department in Al-Shifa center for
the treatment of COVID-19, Baghdad, Iraq
Intensive Care Unit, Bagdad Teaching
Hospital, Medical City Complex, Baghdad,
Faculty of Pharmacy, Philadelphia
University, Amman, Jordan
Ali Azeez Al-Jumaili, University of Iowa,
Iowa City, Iowa, USA.
Email: Aliazeezalifirstname.lastname@example.org, ali.
the management of COVID-19 for all patients. The study was conducted in a public
come measures included the changes in clinical and biochemical parameters during
the hospitalisation period. Paired t-test and Chi-square test were used to compare
the measures of vital signs, lab tests and symptoms before and after treatment.
Results: The study included 161 patients who were admitted with positive RT-PCR
and clinical symptoms of COVID-19. In terms of severity, 53 (32.9%) patients had
amild condition, 47 (29.2%) had moderate condition, 35 (21.7%) had severe condition and 26 (16.1%) had critical condition. Most patients (84.5%) recovered and were
discharged without symptoms after testing negative with RT-PCR, while 11 (6.8%)
patients died during the study period. The signs and symptoms of COVID-19 were
reduced significantly in response to a therapy regimen containing HCQ and azithromycin. The most common reported side effects were stomach pain, hypoglycemia,
dizziness, itching, skin rash, QT prolongation, arrhythmia, and conjunctivitis.
Conclusions: This natural trial showed that the COVID-19 regimen containing both
HCQ and azithromycin can be helpful to promote the recovery of most patients and
reduced their signs and symptoms significantly. It also shows some manageable side
effects mostly those related to heart rhythm. In the absence of FDA-approved medications to treat COVID-19, the repurposing of HCQ and azithromycin to control the
disease signs and symptoms can be useful.
1 | I NTRO D U C TI O N
suggests that it is a beta-corona virus closely linked to the SARS
virus. 2 While most people with COVID-19 develop the only mild or
is less effective
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