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All Studies   Meta Analysis    Recent:   

Intravenous high dose vitamin C and ozonated saline effective treatment for Covid -19: The Evolution of Local Standard of Care

Viglione et al., The Gazette of Medical Sciences, doi:10.46766/thegms.pubheal.22120905
Jan 2023  
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HCQ for COVID-19
1st treatment shown to reduce risk in March 2020
 
*, now known with p < 0.00000000001 from 422 studies, recognized in 42 countries.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
3,900+ studies for 60+ treatments. c19hcq.org
Retrospective 479 high risk outpatients in the USA treated with a protocol including intravenous vitamin C, vitamin D, zinc, quercetin, bromelain, lactoferrin, HCQ, ivermectin, ozonated saline, azithromycin, ceftriaxone, methylprednisolone, dexamethasone, budesonide, and aspirin (protocol varied over time and based on patient characteristics). Authors conclude that the protocol was highly effective. Early treatment was most effective, however authors note that the protocol retained efficacy even with patients presenting late.
Study covers vitamin C, vitamin D, zinc, ivermectin, HCQ, and quercetin.
Viglione et al., 16 Jan 2023, retrospective, USA, peer-reviewed, 4 authors, study period 2 July, 2021 - 8 October, 2021.
This PaperHCQAll
Folding & Prion Disease
K E Thorp, James A Thorp, Elise M Thorp, Margery M Thorp, Paul R Walker, Thorp Ke, Thorp Ja, Paul R Walker This, MD Deborah Viglione
doi:10.46766/thegms.neuro.xxxxxxxxx
048 Intravenous high dose vitamin C and ozonated saline effective treatment for Covid -19: The Evolution of Local Standard of Care
References
Abouhashem, Is Low Alveolar Type II Cell SOD3 in the Lungs of Elderly Linked to the Observed Severity of Covid-19?, Antioxid Redox Signal
Ademowo, Lipid (per) oxidation in mitochondria: an emerging target in the ageing process? Biogerontol
Agrawal, Quercetin: Antiviral Significance and Possible COVID-19 Integrative Considerations, Natural Product Communications, doi:10.1177/1934578X20976293
Al-Kuraishy, Citicoline and COVID-19: vis-à-vis conjectured, Naunyn-Schmiedeberg's Arch Pharmacol, doi:10.1007/s00210-022-02284-6
Bocci, Biological and clinical effects of ozone. Has ozonetherapy a future in medicine?, Br. J. Biomed. Sci
Bocci, Ozone as a bioregulator. Pharmacology and toxicology of ozonetherapy today, J. Biol. Regul. Homeost. Agents
Bocci, Ozonization of blood for the therapy of viral diseases and immunodeficiencies. A hypothesis, Med. Hypotheses
Bocci, Scientific and medical aspects of ozone therapy, state of the art, Arch. Med. Res
Brooks, Oxidative stress in health and disease: the therapeutic potential of Nrf2 activation, Mol Aspects Med, doi:10.1016/j.mam.2011.10.006
Chen, Association between cytokine profiles and lung injury in COVID-19 pneumonia, Respiratory Research volume, doi:10.1186/s12931-020-01465-2#auth-Li_Da-Chen
Chen, Efficacy of HCQ in patients with Covid -19: results of a randomized clinical trial MEDRXIV, doi:10.1101/2020.03.22.20040758v3
Cisterna, Ozone Activates the Nrf2 Pathway and Improves Preservation of Explanted Adipose Tissue In Vitro, Antioxidants, doi:10.3390/antiox9100989
Colson, Chloroquine and hydroxychloroquine as available weapons to fight COVID-19, International Journal of Antimicrobial Agents, doi:10.1016/j.ijantimicag.2020.105932
D'ecclesiis, Vitamin D and Sars CoV-2 infection, severity and mortality: A systematic review and meta-analysis, Med Drug Discov, doi:10.1016/j.medidd.2020.100041PMCID:PMC7189189
Delgado-Roche, Medical ozone promotes Nrf2 phosphorylation reducing oxidative stress and pro-inflammatory cytokines in multiple sclerosis patients, European Journal of Pharmacology, doi:10.1016/j.ejphar.2017.06.017
Derosa, A role for quercetin in coronavirus disease 2019 (COVID-19, Phytotherapy Research, doi:10.1002/ptr.6887
Di Pierro, Quercetin Phytosome as a potential candidate for managing COVID-19, Minerva Gastroenterology, doi:10.23736/s2724-5985.20.02771-3
Donovan, Phytochemical activation of Nrf2 protects human coronary artery endothelial cells against an oxidative challenge, Oxid Med Cell Longev, doi:10.1155/2012/132931
Fernández-Cuadros, Ozone (O3) and Sars CoV-2: physiological bases and their therapeutic possibilities according to COVID-19 evolutionary stage, SN Comprehensive Clinical Medicine
Fink, Bench-to-bedside review: Cytopathic hypoxia, Crit. Care
Gaiter, Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial, Int J Antimicrob Agents
Giunta, Ozonized autohemotransfusion improves hemorhelological parameters and oxygen delivery to tissues in patients with peripheral occlusive artierial disease, Ann Hematol
Hemalika, Phospholipase enzymes as potential biomarker for Sars CoV-2 virus International, Journal of Scientific and Research Publications
Huang, An interferon-γ-related cytokine storm in Sars CoV-2 patients, J. Med. Virol
Jiang, Characterization of cytokine/chemokine profiles of severe acute respiratory syndrome, Am. J. Respir. Crit. Care Med
Johnson, The Nrf2-ARE pathway: an indicator and modulator of oxidative stress in neurodegeneration, Annals of the New York Academy of Sciences
Jothimani, COVID-19: Poor outcomes in patients with zinc deficiency, International Journal of Infectious Diseases
Kazemi, Association of Vitamin D Status with Sars CoV-2 Infection or COVID-19 Severity: A Systematic Review and Meta-analysis Advances in Nutrition, doi:10.1093/advances/nmab012
Kaźmierczak-Barańska, Two Faces of Vitamin C-Antioxidative and pro-Oxidative Agent Nutrients, doi:10.3390/nu12051501
Khomich, Redox Biology of Respiratory Viral Infections, Viruses
Konrad, Ozone therapy for herpes simplex and herpes zoster
Kouhbayeh, The molecular story of COVID -19; NAD+ depletion addresses all questions in this infection
Levy, Curing the Incurable Chapter 2 -Page 51
Liguori, Oxidative stress, aging, and diseases, Clinical interventions in aging
Lim, Protandim Protects Oligodendrocytes against an Oxidative Insult, Antioxidants
Liu, HCQ, a less toxic derivative of chloroquine, is effective in inhibiting Sars CoV-2 infection in vitro, NATURE Mar
Manjunath, Recent Case Studies on the Use of Ozone to Combat Coronavirus: Problems and Perspectives, Environ Technol Innov
Mantzarlis, Role of Oxidative Stress and Mitochondrial Dysfunction in Sepsis and Potential Therapies, Oxid. Med. Cell Longev
Marik, Does vitamin D status impact mortality from Sars CoV-2 infection? Medicine in drug discovery
Mattassi, Ozone as therapy in herpes simplex and herpes zoster diseases, in Medical applications of ozone
Mccullough, Pathophysiological basis and rationale for early outpatient treatment of Sars CoV-2 (COVID-19) infection, The American journal of medicine
Mendonca, Flavonoids Activation of the Transcription Factor Nrf2 as a Hypothesis Approach for the Prevention and Modulation of Sars CoV-2 Infection Severity, Antioxidants, doi:10.3390/antiox9080659
Miotto, Lactoferrin Against Sars CoV-2: In Vitro and In Silico Evidences for a two receptor based strategy of Sars CoV-2 Front, Structural Biology, doi:10.3389/fmolb.2021.690655
Miotto, Molecular mechanisms behind anti Sars CoV-2 action of lactoferrin -Front, doi:10.3389/fmolb.2021.607443
Pal, Zinc and COVID-19: Basis of Current Clinical Trials, Biol Trace Elem Res, doi:10.1007/s12011-020-02437-9
Pall, Nrf2 Regulator of detoxification, antioxidant, anti-inflammatory and cytoprotection is raised by health promoting factors
Peipei, Cytokine storm induced by Sars CoV-2, Clin Chim Acta, doi:10.1016/j.cca.2020.06.017
Pierro, Potential clinical benefits of quercetin in the early stage of COVID-19: results of a second, pilot, randomized, controlled and open-label clinical trial, Int J Gen Med, doi:10.2147/IJGM.S318949
Re, Is ozone pre-conditioning effect linked to Nrf2/EpRE activation pathway in vivo? A preliminary result, European Journal of Pharmacology, doi:10.1016/j.ejphar.2014.08.029
Reang, Understanding the Therapeutic Potential of Ascorbic Acid in the Battle to Overcome Cancer Biomolecules, doi:10.3390/biom11081130
Reuland, Nrf2 protects cardiomyocytes against oxidant stress, doi:10.1016/j.freeradbiomed.2012.11.016
Ricevuti, Oxygen-ozone immunoceutical therapy in COVID-19 outbreak: facts and figures
Romano, Oxidative stress and aging, Journal of Nephrology
Rowen, A plausible "penny" costing effective treatment for corona virusozone therapy, J. Infect. Dis. Epidemiol
Sagai, Mechanisms of Action Involved in Ozone Therapy: Is healing induced via a mild oxidative stress?, Med Gas Res, doi:10.1186/2045-9912-1-29
Shah, Safety and efficacy of ozone therapy in mild to moderate COVID-19 patients: A phase 1/11 randomized control trial (SEOT study), International immunopharmacology
Shaw, Webinar
Sioot, Lanham-New, Vitamin D and Sars CoV-2 virus/COVID-19 disease, BMJ Nutr Prev Health, doi:10.1136/bmjnph-2020-000089PMCID:PMC7246103PMID:33230499
Suh, Decline in transcriptional activity of Nrf2 causes age-related loss of glutathione synthesis, which is reversible with lipoic acid Biochemistry Proceedings of the …, National Acad Sciences, doi:10.1073/pnas.0400282101
Sun, Vitamin C pharmacokinetics: implications for oral and intravenous use, Ann Intern Med, doi:10.7326/0003-4819-140-7-200404060-00010
Takeda, Plasma lipid peroxides and alpha-tocopherol in critically ill patients, Crit. Care Med
Thorp, Aether, fields & energy dynamics in living bodies -Part I, G Med Sci, doi:10.46766/thegms.medphys.21100603
Thorp, Aether, fields & energy dynamics in living bodies -Part II, G Med Sci, doi:10.46766/thegms.medphys.21110401
Thorp, Aether, fields & energy dynamics in living bodies -Part III, G Med Sci, doi:10.46766/thegms.medphys.21112203
Thorp, COVID-19 & Disaster Capitalism -Part I, G Med Sci, doi:10.46766/thegms.medethics.22071901
Thorp, Global COVID-19 Pandemic Outcomes: Dissecting a Failed Strategy, Preprints, doi:10.20944/preprints202211.0480.v1
Thorp, Novel therapy for COVID-19 does intravenous ozonated-saline affect blood and tissue oxygenation?, Journal of Gynecological Research and Obstetrics
Thorp, Ozone Preconditioning: Waking up the dragon, G Med Sci, doi:10.46766/thegms.intmed.21051402
Thorp, Patient Betrayal: The Corruption of Healthcare, Informed Consent and the Physician-Patient Relationship, G Med Sci, doi:10.46766/thegms.medethics.22021403
Toldo, Inflammasome formation in the lungs of patients with fatal COVID-19, Inflamm. Res, doi:10.1007/s00011-020-01413-2
Triantafilou, Ion flux in the lung: virus-induced inflammasome activation, Trends Microbiol
Van Den Brand, The pathology and pathogenesis of experimental severe acute respiratory syndrome and influenza in animal models, J. Comp. Pathol
Velmurugan, Synergistic induction of heme oxygenase-1 by the components of the antioxidant supplement Protandim S, Free Radic Biol Med, doi:10.1016/j.freeradbiomed.2008.10.050
Wessels, The potential impact of zinc supplementation on COVID-19 pathogenesis Frontiers in immunology, doi:10.3389/fimmu.2020.01712/full?fbclid=IwAR2dMknldDOCu3guYNVNMmZ7dBRC_-CU1yyaVWcEzghbFmaDMtaj0IUrohI
Wilson, Review of high-dose intravenous vitamin C as an anticancer agent, Asia Pac J Clin Oncol, doi:10.1111/ajco.12173
Worldometers, None
Wu, Free radicals, antioxidant defense systems, and schizophrenia, Prog Neuropsychopharmacol Biol Psychiatry
Zeng, Longitudinal changes of inflammatory parameters and their correlation with disease severity and outcomes in patients with COVID-19 from Wuhan, doi:10.1186/s13054-020-03255-0#auth-Zhilin-Zeng
Zheng, A preliminary evaluation on the efficacy of ozone therapy in the treatment of COVID-19, Journal of medical virology
Zimecki, The potential for Lactoferrin to reduce Sars CoV-2 induced cytokine storm, Front Pharmacol, doi:10.3389/fphar.2021.666600.eCollection2021
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