Abstract: medRxiv preprint doi: https://doi.org/10.1101/2020.10.09.20209775; this version posted October 11, 2020. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license . Factors associated with progression to critical illness in 28 days among COVID-19 patients: results from a tertiary care hospital in Istanbul, Turkey # Uluhan Sili* , Pinar Ay*, Ahmet Topuzoglu*, Huseyin Bilgin*, Elif Tukenmez Tigen, Buket Erturk Sengel, Dilek Yagci Caglayik, Baran Balcan, Derya Kocakaya, Sehnaz Olgun Yildizeli, Fethi Gul, Beliz Bilgili, Rabia Can Sarinoglu, Aysegul Karahasan Yagci, Lutfiye Mulazimoglu Durmusoglu, Emel Eryuksel, Zekaver Odabasi, Haner Direskeneli, Sait Karakurt, Ismail Cinel, Volkan Korten # * equal contribution # corresponding authors Uluhan Sili, Huseyin Bilgin, Elif Tukenmez Tigen, Buket Erturk Sengel, Dilek Yagci Caglayik, Lutfiye Mulazimoglu Durmusoglu, Zekaver Odabasi, Volkan Korten, Department of Infectious Diseases and Clinical Microbiology, Marmara University School of Medicine, Istanbul, Turkey Pinar Ay, Ahmet Topuzoglu, Department of Public Health, Marmara University School of Medicine, Istanbul, Turkey Baran Balcan, Derya Kocakaya, Sehnaz Olgun Yildizeli, Emel Eryuksel, Sait Karakurt, Department of Pulmonary Medicine, Marmara University School of Medicine, Istanbul, Turkey Fethi Gul, Beliz Bilgili, Ismail Cinel, Department of Anesthesiology and Intensive Care, Marmara University School of Medicine, Istanbul, Turkey 1 NOTE: This preprint reports new research that has not been certified by peer review and should not be used to guide clinical practice. medRxiv preprint doi: https://doi.org/10.1101/2020.10.09.20209775; this version posted October 11, 2020. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license . Rabia Can Sarinoglu, Aysegul Karahasan Yagci, Department of Medical Microbiology, Marmara University School of Medicine, Istanbul, Turkey Haner Direskeneli, Department of Internal Medicine, Marmara University School of Medicine, Istanbul, Turkey Keywords: COVID-19, prospective cohort, critical illness, prognosis Running title: Critical illness development in COVID-19 Corresponding author: Uluhan Sili, MD, PhD Address: Department of Infectious Diseases and Clinical Microbiology, Marmara University School of Medicine, Pendik Training and Research Hospital, 34896, Istanbul, Turkey Telephone: +90 505 746 5265 (mobile), +90 216 625 4693 (work) Fax: +90 216 625 4790 E-mail: uluhan@hotmail.com ; uluhan.sili@marmara.edu.tr Alternate corresponding author: Volkan Korten, MD Address: Department of Infectious Diseases and Clinical Microbiology, Marmara University School of Medicine, Pendik Training and Research Hospital, 34896, Istanbul, Turkey Telephone: +90 (532) 261 55 58 (mobile), +90 216 625 45 38 (work) Fax: +90 216 625 4790 E-mail: vkorten@gmail.com ; korten@marmara.edu.tr 2 medRxiv preprint doi: https://doi.org/10.1101/2020.10.09.20209775; this version posted October 11, 2020. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted medRxiv a license to display the preprint in..