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'title': 'Molnupiravir, a ribonucleoside antiviral prodrug against SARS-CoV-2, alters the voltage-gated '
'sodium current and causes adverse events',
'prefix': '10.1016',
'author': [ {'given': 'Ai-Li', 'family': 'Shiau', 'sequence': 'first', 'affiliation': []},
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'reference': [ { 'issue': '17',
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'doi-asserted-by': 'crossref',
'first-page': '4602',
'DOI': '10.1523/JNEUROSCI.5204-05.2006',
'article-title': 'Interaction of Kv3 potassium channels and resurgent sodium current '
'influences the rate of spontaneous firing of Purkinje neurons',
'volume': '26',
'author': 'Akemann',
'year': '2006',
'journal-title': 'J. Neurosci.'},
{ 'issue': '1',
'key': '10.1016/j.virol.2023.109865_bib2',
'doi-asserted-by': 'crossref',
'first-page': '5',
'DOI': '10.1177/1756283X11415892',
'article-title': 'Targeting ion channels for the treatment of gastrointestinal motility '
'disorders',
'volume': '5',
'author': 'Beyder',
'year': '2012',
'journal-title': 'Therap Adv Gastroenterol'},
{ 'issue': '7',
'key': '10.1016/j.virol.2023.109865_bib3',
'doi-asserted-by': 'crossref',
'first-page': '1659',
'DOI': '10.1053/j.gastro.2014.02.054',
'article-title': 'Loss-of-function of the voltage-gated sodium channel NaV1.5 '
'(channelopathies) in patients with irritable bowel syndrome',
'volume': '146',
'author': 'Beyder',
'year': '2014',
'journal-title': 'Gastroenterology'},
{ 'key': '10.1016/j.virol.2023.109865_bib4',
'doi-asserted-by': 'crossref',
'first-page': '133',
'DOI': '10.1146/annurev-pharmtox-010818-021757',
'article-title': 'Structure and pharmacology of voltage-gated sodium and calcium channels',
'volume': '60',
'author': 'Catterall',
'year': '2020',
'journal-title': 'Annu. Rev. Pharmacol. Toxicol.'},
{ 'key': '10.1016/j.virol.2023.109865_bib5',
'doi-asserted-by': 'crossref',
'first-page': '1091',
'DOI': '10.3389/fphar.2020.01091',
'article-title': 'Evidence for the effectiveness of remdesivir (GS-5734), a '
'nucleoside-analog anti-viral drug in the inhibition of Ik(M) or Ik(DR) '
'and in the stimulation of IMEP',
'volume': '11',
'author': 'Chang',
'year': '2020',
'journal-title': 'Front. Pharmacol.'},
{ 'issue': '5',
'key': '10.1016/j.virol.2023.109865_bib6',
'doi-asserted-by': 'crossref',
'DOI': '10.3390/biomedicines9050549',
'article-title': 'Characterization of direct perturbations on voltage-gated sodium '
'current by esaxerenone, a nonsteroidal mineralocorticoid receptor '
'blocker',
'volume': '9',
'author': 'Chang',
'year': '2021',
'journal-title': 'Biomedicines'},
{ 'issue': '3',
'key': '10.1016/j.virol.2023.109865_bib7',
'doi-asserted-by': 'crossref',
'first-page': '295',
'DOI': '10.1254/jphs.09018FP',
'article-title': 'Effects of ranolazine, a novel anti-anginal drug, on ion currents and '
'membrane potential in pituitary tumor GH(3) cells and NG108-15 neuronal '
'cells',
'volume': '110',
'author': 'Chen',
'year': '2009',
'journal-title': 'J. Pharmacol. Sci.'},
{ 'issue': '2',
'key': '10.1016/j.virol.2023.109865_bib8',
'doi-asserted-by': 'crossref',
'first-page': '244',
'DOI': '10.1093/bja/aep107',
'article-title': 'Dexmedetomidine, an alpha2-adrenergic agonist, inhibits neuronal '
'delayed-rectifier potassium current and sodium current',
'volume': '103',
'author': 'Chen',
'year': '2009',
'journal-title': 'Br. J. Anaesth.'},
{ 'issue': '3',
'key': '10.1016/j.virol.2023.109865_bib9',
'doi-asserted-by': 'crossref',
'DOI': '10.3390/biomedicines10030721',
'article-title': 'Activation of voltage-gated Na(+) current by GV-58, a known activator '
'of Ca(V) channels',
'volume': '10',
'author': 'Cho',
'year': '2022',
'journal-title': 'Biomedicines'},
{ 'issue': '1',
'key': '10.1016/j.virol.2023.109865_bib10',
'doi-asserted-by': 'crossref',
'DOI': '10.3390/biomedicines10010086',
'article-title': 'The evidence for sparsentan-mediated inhibition of I(Na) and I(K(erg)): '
'possibly unlinked to its antagonism of angiotensin II or endothelin '
'type a receptor',
'volume': '10',
'author': 'Chuang',
'year': '2021',
'journal-title': 'Biomedicines'},
{ 'issue': '10',
'key': '10.1016/j.virol.2023.109865_bib11',
'article-title': 'Ionic mechanisms maintaining action potential conduction velocity at '
'high firing frequencies in an unmyelinated axon',
'volume': '4',
'author': 'Cross',
'year': '2016',
'journal-title': 'Phys. Rep.'},
{ 'issue': '15–16',
'key': '10.1016/j.virol.2023.109865_bib12',
'doi-asserted-by': 'crossref',
'first-page': '564',
'DOI': '10.1016/j.lfs.2011.05.016',
'article-title': 'Resurgent Na+ current: a new avenue to neuronal excitability control',
'volume': '89',
'author': 'Cruz',
'year': '2011',
'journal-title': 'Life Sci.'},
{ 'issue': '18',
'key': '10.1016/j.virol.2023.109865_bib13',
'doi-asserted-by': 'crossref',
'first-page': '7093',
'DOI': '10.1021/jm501981g',
'article-title': 'Voltage-gated sodium channels: structure, function, pharmacology, and '
'clinical indications',
'volume': '58',
'author': 'de Lera Ruiz',
'year': '2015',
'journal-title': 'J. Med. Chem.'},
{ 'issue': '2',
'key': '10.1016/j.virol.2023.109865_bib14',
'doi-asserted-by': 'crossref',
'first-page': '305',
'DOI': '10.1002/jnr.24134',
'article-title': 'Development of resurgent and persistent sodium currents in '
'mesencephalic trigeminal neurons',
'volume': '96',
'author': 'Enomoto',
'year': '2018',
'journal-title': 'J. Neurosci. Res.'},
{ 'issue': '1',
'key': '10.1016/j.virol.2023.109865_bib15',
'doi-asserted-by': 'crossref',
'DOI': '10.1016/j.celrep.2021.108940',
'article-title': 'Anti-viral drug screen identifies DNA-damage response inhibitor as '
'potent blocker of SARS-CoV-2 replication',
'volume': '35',
'author': 'Garcia',
'year': '2021',
'journal-title': 'Cell Rep.'},
{ 'issue': '1',
'key': '10.1016/j.virol.2023.109865_bib16',
'doi-asserted-by': 'crossref',
'first-page': '62',
'DOI': '10.1016/j.neulet.2009.01.066',
'article-title': 'mu-Opioid receptor-independent fashion of the suppression of sodium '
'currents by mu-opioid analgesics in thalamic neurons',
'volume': '453',
'author': 'Hashimoto',
'year': '2009',
'journal-title': 'Neurosci. Lett.'},
{ 'issue': '3',
'key': '10.1016/j.virol.2023.109865_bib17',
'doi-asserted-by': 'crossref',
'first-page': '423',
'DOI': '10.1113/JP275083',
'article-title': 'Resurgent sodium current promotes action potential firing in the avian '
'auditory brainstem',
'volume': '596',
'author': 'Hong',
'year': '2018',
'journal-title': 'J. Physiol.'},
{ 'issue': '6',
'key': '10.1016/j.virol.2023.109865_bib18',
'doi-asserted-by': 'crossref',
'first-page': '1318',
'DOI': '10.3390/biomedicines10061318',
'article-title': 'Inhibitory effectiveness in delayed-rectifier potassium current caused '
'by vortioxetine, known to Be a novel antidepressant',
'volume': '10',
'author': 'Hsiao',
'year': '2022',
'journal-title': 'Biomedicines'},
{ 'key': '10.1016/j.virol.2023.109865_bib19',
'doi-asserted-by': 'crossref',
'first-page': '125',
'DOI': '10.1016/j.neuroscience.2014.12.026',
'article-title': 'The inhibitory actions by lacosamide, a functionalized amino acid, on '
'voltage-gated Na+ currents',
'volume': '287',
'author': 'Huang',
'year': '2015',
'journal-title': 'Neuroscience'},
{ 'issue': '19',
'key': '10.1016/j.virol.2023.109865_bib20',
'doi-asserted-by': 'crossref',
'DOI': '10.3390/molecules26195795',
'article-title': 'Discovery, development, and patent trends on molnupiravir: a '
'prospective oral treatment for COVID-19',
'volume': '26',
'author': 'Imran',
'year': '2021',
'journal-title': 'Molecules'},
{ 'issue': '6',
'key': '10.1016/j.virol.2023.109865_bib21',
'doi-asserted-by': 'crossref',
'first-page': '509',
'DOI': '10.1056/NEJMoa2116044',
'article-title': 'Molnupiravir for oral treatment of covid-19 in nonhospitalized patients',
'volume': '386',
'author': 'Jayk Bernal',
'year': '2022',
'journal-title': 'N. Engl. J. Med.'},
{ 'issue': '2',
'key': '10.1016/j.virol.2023.109865_bib22',
'doi-asserted-by': 'crossref',
'first-page': '164',
'DOI': '10.2174/09298673113206660257',
'article-title': 'Isoform selective voltage-gated sodium channel modulators and the '
'therapy of pain',
'volume': '21',
'author': 'Jukič',
'year': '2014',
'journal-title': 'Curr. Med. Chem.'},
{ 'issue': '17',
'key': '10.1016/j.virol.2023.109865_bib23',
'doi-asserted-by': 'crossref',
'first-page': '6639',
'DOI': '10.1523/JNEUROSCI.17-17-06639.1997',
'article-title': 'Prolonged sodium channel inactivation contributes to dendritic action '
'potential attenuation in hippocampal pyramidal neurons',
'volume': '17',
'author': 'Jung',
'year': '1997',
'journal-title': 'J. Neurosci.'},
{ 'issue': '9',
'key': '10.1016/j.virol.2023.109865_bib24',
'doi-asserted-by': 'crossref',
'first-page': '740',
'DOI': '10.1038/s41594-021-00651-0',
'article-title': 'Mechanism of molnupiravir-induced SARS-CoV-2 mutagenesis',
'volume': '28',
'author': 'Kabinger',
'year': '2021',
'journal-title': 'Nat. Struct. Mol. Biol.'},
{ 'issue': '1',
'key': '10.1016/j.virol.2023.109865_bib25',
'doi-asserted-by': 'crossref',
'first-page': '162',
'DOI': '10.1124/mol.113.088492',
'article-title': 'Ranolazine reduces neuronal excitability by interacting with '
'inactivated states of brain sodium channels',
'volume': '85',
'author': 'Kahlig',
'year': '2014',
'journal-title': 'Mol. Pharmacol.'},
{ 'issue': '12',
'key': '10.1016/j.virol.2023.109865_bib26',
'doi-asserted-by': 'crossref',
'first-page': '4899',
'DOI': '10.1523/JNEUROSCI.23-12-04899.2003',
'article-title': 'The contribution of resurgent sodium current to high-frequency firing '
'in Purkinje neurons: an experimental and modeling study',
'volume': '23',
'author': 'Khaliq',
'year': '2003',
'journal-title': 'J. Neurosci.'},
{ 'issue': '1',
'key': '10.1016/j.virol.2023.109865_bib27',
'doi-asserted-by': 'crossref',
'first-page': '2342',
'DOI': '10.1038/s41467-019-10280-3',
'article-title': 'Structure of the SARS-CoV nsp12 polymerase bound to nsp7 and nsp8 '
'co-factors',
'volume': '10',
'author': 'Kirchdoerfer',
'year': '2019',
'journal-title': 'Nat. Commun.'},
{ 'issue': '22',
'key': '10.1016/j.virol.2023.109865_bib28',
'doi-asserted-by': 'crossref',
'first-page': '4825',
'DOI': '10.1113/jphysiol.2014.277582',
'article-title': 'Resurgent current of voltage-gated Na(+) channels',
'volume': '592',
'author': 'Lewis',
'year': '2014',
'journal-title': 'J. Physiol.'},
{ 'issue': 'Pt 1',
'key': '10.1016/j.virol.2023.109865_bib29',
'doi-asserted-by': 'crossref',
'first-page': '83',
'DOI': '10.1113/jphysiol.2006.106682',
'article-title': 'Kinetic and functional analysis of transient, persistent and resurgent '
'sodium currents in rat cerebellar granule cells in situ: an '
'electrophysiological and modelling study',
'volume': '573',
'author': 'Magistretti',
'year': '2006',
'journal-title': 'J. Physiol.'},
{ 'key': '10.1016/j.virol.2023.109865_bib30',
'first-page': '1',
'article-title': 'Efficacy and safety of Molnupiravir in COVID-19 patients: a systematic '
'review',
'author': 'Mali',
'year': '2022',
'journal-title': 'Ir. J. Med. Sci.'},
{ 'issue': '6',
'key': '10.1016/j.virol.2023.109865_bib31',
'doi-asserted-by': 'crossref',
'DOI': '10.3390/antiox10060979',
'article-title': 'Electron donor-acceptor capacity of selected pharmaceuticals against '
'COVID-19',
'volume': '10',
'author': 'Martínez',
'year': '2021',
'journal-title': 'Antioxidants'},
{ 'issue': '1',
'key': '10.1016/j.virol.2023.109865_bib32',
'doi-asserted-by': 'crossref',
'DOI': '10.1016/j.jbc.2021.100867',
'article-title': 'Decoding molnupiravir-induced mutagenesis in SARS-CoV-2',
'volume': '297',
'author': 'Menéndez-Arias',
'year': '2021',
'journal-title': 'J. Biol. Chem.'},
{ 'key': '10.1016/j.virol.2023.109865_bib33',
'doi-asserted-by': 'crossref',
'DOI': '10.7554/eLife.54940',
'article-title': 'Sodium channels implement a molecular leaky integrator that detects '
'action potentials and regulates neuronal firing',
'volume': '9',
'author': 'Navarro',
'year': '2020',
'journal-title': 'Elife'},
{ 'issue': '2',
'key': '10.1016/j.virol.2023.109865_bib34',
'first-page': '167',
'article-title': 'Aconitine-induced modification of single sodium channels in '
'neuroblastoma cell membrane',
'volume': '9',
'author': 'Negulyaev Yu',
'year': '1990',
'journal-title': 'Gen. Physiol. Biophys.'},
{ 'key': '10.1016/j.virol.2023.109865_bib35',
'doi-asserted-by': 'crossref',
'first-page': '17',
'DOI': '10.1016/j.coviro.2021.06.003',
'article-title': 'Developing a direct acting, orally available anti-viral agent in a '
'pandemic: the evolution of molnupiravir as a potential treatment for '
'COVID-19',
'volume': '50',
'author': 'Painter',
'year': '2021',
'journal-title': 'Curr Opin Virol'},
{ 'issue': '5',
'key': '10.1016/j.virol.2023.109865_bib36',
'doi-asserted-by': 'crossref',
'DOI': '10.1128/AAC.02428-20',
'article-title': 'Human safety, tolerability, and pharmacokinetics of molnupiravir, a '
'novel broad-spectrum oral anti-viral agent with activity against '
'SARS-CoV-2',
'volume': '65',
'author': 'Painter',
'year': '2021',
'journal-title': 'Antimicrob. Agents Chemother.'},
{ 'key': '10.1016/j.virol.2023.109865_bib37',
'doi-asserted-by': 'crossref',
'DOI': '10.3389/fncel.2021.760610',
'article-title': 'Resurgent sodium current in neurons of the cerebral cortex',
'volume': '15',
'author': 'Quattrocolo',
'year': '2021',
'journal-title': 'Front. Cell. Neurosci.'},
{ 'issue': '7',
'key': '10.1016/j.virol.2023.109865_bib38',
'doi-asserted-by': 'crossref',
'first-page': '553',
'DOI': '10.1038/nrn1430',
'article-title': 'The neurobiology of antiepileptic drugs',
'volume': '5',
'author': 'Rogawski',
'year': '2004',
'journal-title': 'Nat. Rev. Neurosci.'},
{ 'issue': '6',
'key': '10.1016/j.virol.2023.109865_bib39',
'doi-asserted-by': 'crossref',
'DOI': '10.1016/j.dsx.2021.102329',
'article-title': 'Molnupiravir in COVID-19: a systematic review of literature',
'volume': '15',
'author': 'Singh',
'year': '2021',
'journal-title': 'Diabetes Metabol. Syndr.'},
{ 'key': '10.1016/j.virol.2023.109865_bib40',
'doi-asserted-by': 'crossref',
'first-page': '104',
'DOI': '10.1016/j.toxlet.2018.01.002',
'article-title': 'Differential regulation of tefluthrin and telmisartan on the gating '
'charges of INa activation and inactivation as well as on resurgent and '
'persistent INa in a pituitary cell line (GH3)',
'volume': '285',
'author': 'So',
'year': '2018',
'journal-title': 'Toxicol. Lett.'},
{ 'issue': '5',
'key': '10.1016/j.virol.2023.109865_bib41',
'doi-asserted-by': 'crossref',
'first-page': '2053',
'DOI': '10.1159/000475436',
'article-title': 'Synergistic inhibition of delayed rectifier K+ and voltage-gated Na+ '
'currents by artemisinin in pituitary tumor (GH3) cells',
'volume': '41',
'author': 'So',
'year': '2017',
'journal-title': 'Cell. Physiol. Biochem.'},
{ 'key': '10.1016/j.virol.2023.109865_bib42',
'doi-asserted-by': 'crossref',
'first-page': '845',
'DOI': '10.1210/er.2010-0005',
'article-title': 'Ion channels and signaling in the pituitary gland',
'volume': '31',
'author': 'Stojilkov',
'year': '2010',
'journal-title': 'Endocr. Rev.'},
{ 'issue': '6',
'key': '10.1016/j.virol.2023.109865_bib43',
'doi-asserted-by': 'crossref',
'first-page': '1160',
'DOI': '10.1016/j.molcel.2020.12.048',
'article-title': 'A tamoxifen receptor within a voltage-gated sodium channel',
'volume': '81',
'author': 'Sula',
'year': '2021',
'journal-title': 'Mol. Cell'},
{ 'key': '10.1016/j.virol.2023.109865_bib44',
'doi-asserted-by': 'crossref',
'first-page': '338',
'DOI': '10.2119/molmed.2016.00131',
'article-title': 'A gain-of-function mutation in Nav1.6 in a case of trigeminal neuralgia',
'volume': '22',
'author': 'Tanaka',
'year': '2016',
'journal-title': 'Mol. Med.'},
{ 'issue': '3',
'key': '10.1016/j.virol.2023.109865_bib45',
'doi-asserted-by': 'crossref',
'first-page': '275',
'DOI': '10.3748/wjg.v28.i3.275',
'article-title': 'Endothelial cells and blood vessels are major targets for '
'COVID-19-induced tissue injury and spreading to various organs',
'volume': '28',
'author': 'Tarnawski',
'year': '2022',
'journal-title': 'World J. Gastroenterol.'},
{ 'key': '10.1016/j.virol.2023.109865_bib46',
'doi-asserted-by': 'crossref',
'DOI': '10.3389/fimmu.2022.855496',
'article-title': 'Molnupiravir and its anti-viral activity against COVID-19',
'volume': '13',
'author': 'Tian',
'year': '2022',
'journal-title': 'Front. Immunol.'},
{ 'key': '10.1016/j.virol.2023.109865_bib47',
'doi-asserted-by': 'crossref',
'DOI': '10.1016/j.antiviral.2022.105252',
'article-title': 'Remdesivir, Molnupiravir and Nirmatrelvir remain active against '
'SARS-CoV-2 Omicron and other variants of concern',
'volume': '198',
'author': 'Vangeel',
'year': '2022',
'journal-title': 'Antivir. Res.'},
{ 'issue': '6',
'key': '10.1016/j.virol.2023.109865_bib48',
'doi-asserted-by': 'crossref',
'DOI': '10.1371/journal.pcbi.1007154',
'article-title': 'Resurgent Na+ current offers noise modulation in bursting neurons',
'volume': '15',
'author': 'Venugopal',
'year': '2019',
'journal-title': 'PLoS Comput. Biol.'},
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'key': '10.1016/j.virol.2023.109865_bib49',
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'DOI': '10.3390/ijms23073845',
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'((1R,5S,6S)-6-(aminomethyl)-3-ethyl-bicyclo [3.2.0] hept-3-ene-6-acetic '
'acid), a known blocker of Ca(V) channels',
'volume': '23',
'author': 'Wu',
'year': '2022',
'journal-title': 'Int. J. Mol. Sci.'},
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'key': '10.1016/j.virol.2023.109865_bib50',
'doi-asserted-by': 'crossref',
'first-page': '3409',
'DOI': '10.1002/jcp.25788',
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'volume': '232',
'author': 'Wu',
'year': '2017',
'journal-title': 'J. Cell. Physiol.'},
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'key': '10.1016/j.virol.2023.109865_bib51',
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'DOI': '10.3390/ijms22062956',
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'volume': '22',
'author': 'Wu',
'year': '2021',
'journal-title': 'Int. J. Mol. Sci.'},
{ 'issue': '1',
'key': '10.1016/j.virol.2023.109865_bib52',
'doi-asserted-by': 'crossref',
'first-page': '70',
'DOI': '10.1016/j.tox.2009.01.009',
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'insecticide, on voltage-gated ion currents and on action currents in '
'pituitary tumor (GH3) cells and GnRH-secreting (GT1-7) neurons',
'volume': '258',
'author': 'Wu',
'year': '2009',
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'key': '10.1016/j.virol.2023.109865_bib53',
'doi-asserted-by': 'crossref',
'first-page': '120',
'DOI': '10.1111/j.1748-1716.2012.02438.x',
'article-title': 'Electrophysiological characterization of sodium-activated potassium '
'channels in NG108-15 and NSC-34 motor neuron-like cells',
'volume': '206',
'author': 'Wu',
'year': '2012',
'journal-title': 'Acta Physiol.'},
{ 'issue': '1',
'key': '10.1016/j.virol.2023.109865_bib54',
'first-page': '1',
'article-title': 'Molnupiravir, favipiravir and other anti-viral drugs with proposed '
'potentials for management of COVID-19: a concern on antioxidant aspect',
'volume': '13',
'author': 'Yasri',
'year': '2022',
'journal-title': 'Int J Biochem Mol Biol'},
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'first-page': '1',
'article-title': 'Review on molnupiravir as a promising oral drug for the treatment of '
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'author': 'Zarenezhad',
'year': '2022',
'journal-title': 'Med. Chem. Res.'},
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'key': '10.1016/j.virol.2023.109865_bib56',
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'first-page': '6762',
'DOI': '10.1038/s41467-021-26521-3',
'article-title': 'Resurgent Na(+) currents promote ultrafast spiking in projection '
'neurons that drive fine motor control',
'volume': '12',
'author': 'Zemel',
'year': '2021',
'journal-title': 'Nat. Commun.'},
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'doi-asserted-by': 'crossref',
'first-page': '410',
'DOI': '10.1038/s41392-021-00837-4',
'article-title': 'A novel model of molnupiravir against SARS-CoV-2 replication: '
'accumulated RNA mutations to induce error catastrophe',
'volume': '6',
'author': 'Zhao',
'year': '2021',
'journal-title': 'Signal Transduct. Targeted Ther.'}],
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