Prophylaxis RCT in Singapore with 3,037 low risk patients, showing lower serious cases, lower symptomatic cases, and lower confirmed cases of COVID-19 with all treatments (ivermectin, HCQ, PVP-I, and Zinc + vitamin C) compared to vitamin C.
Only 71.4% reported >70% adherence, limiting efficacy.
QTc did not statistically significantly differ between baseline and follow-up readings (mean 379 vs 378ms, paired t-test p
Meta-analysis of vitamin C in 6 previous trials shows a benefit of 16%, so the actual benefit of ivermectin, HCQ, and PVP-I may be higher. Cluster RCT with 40 clusters.
There were no hospitalizations and no deaths. NCT04446104 (history)
Seet et al., 14 Apr 2021, Cluster Randomized Controlled Trial, Singapore, peer-reviewed, 15 authors, dosage 400mg day 1, 200mg days 2-42, this trial compares with another treatment - results may be better when compared to placebo, trial NCT04446104 (history)