Analgesics
Antiandrogens
Antihistamines
Azvudine
Bromhexine
Budesonide
Colchicine
Conv. Plasma
Curcumin
Famotidine
Favipiravir
Fluvoxamine
Hydroxychlor..
Ivermectin
Lifestyle
Melatonin
Metformin
Minerals
Molnupiravir
Monoclonals
Naso/orophar..
Nigella Sativa
Nitazoxanide
PPIs
Paxlovid
Quercetin
Remdesivir
Thermotherapy
Vitamins
More

Other
Feedback
Home
Top
Abstract
All HCQ studies
Meta analysis
 
Feedback
Home
next
study
previous
study
c19hcq.org COVID-19 treatment researchHCQHCQ (more..)
Melatonin Meta
Metformin Meta
Antihistamines Meta
Azvudine Meta Molnupiravir Meta
Bromhexine Meta
Budesonide Meta
Colchicine Meta Nigella Sativa Meta
Conv. Plasma Meta Nitazoxanide Meta
Curcumin Meta PPIs Meta
Famotidine Meta Paxlovid Meta
Favipiravir Meta Quercetin Meta
Fluvoxamine Meta Remdesivir Meta
Hydroxychlor.. Meta Thermotherapy Meta
Ivermectin Meta

All Studies   Meta Analysis    Recent:   

Efficacy of chloroquine and hydroxychloroquine in the treatment of COVID-19

Meo et al., Eur. Rev. Med. Pharmacol. Sci. 2020, 24 (8), 4539-4547, doi:10.26355/eurrev_202004_21038
Apr 2020  
  Post
  Facebook
Share
  Source   PDF   All Studies   Meta AnalysisMeta
HCQ for COVID-19
1st treatment shown to reduce risk in March 2020
 
*, now with p < 0.00000000001 from 417 studies, recognized in 46 countries.
No treatment is 100% effective. Protocols combine treatments. * >10% efficacy, ≥3 studies.
4,800+ studies for 102 treatments. c19hcq.org
Analysis of COVID-19 and malaria, finding that COVID-19 is highly pandemic in countries where malaria is least pandemic, and vice versa, suggesting that CQ/HCQ (widely used for malaria) are protective for COVID-19. This paper also includes a review of 9 articles supporting the efficacy of HCQ and CQ.
Meo et al., 30 Apr 2020, peer-reviewed, 3 authors.
This PaperHCQAll
{ 'type': 'article-journal', 'language': 'eng', 'author': [ {'family': 'Meo', 'given': 'S.A.'}, {'family': 'Klonoff', 'given': 'D.C.'}, {'family': 'Akram', 'given': 'J.'}], 'issued': {'date-parts': [[2020, 4]]}, 'abstract': 'OBJECTIVE: The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), also ' 'called COVID-19, has caused a pandemic which has swiftly involved the entire world and raised ' 'great public health concerns. The scientific community is actively exploring treatments that ' 'would potentially be effective in combating COVID-19. Hydroxychloroquine has been ' 'demonstrated to limit the replication of SARS-CoV-2 virus in vitro. In malarial pandemic ' 'countries, chloroquine is widely used to treat malaria. In malarial non-pandemic nations, ' 'chloroquine is not widely used. Chloroquine and hydroxychloroquine share similar chemical ' 'structures and mechanisms of action. The aim of this study was to indirectly investigate the ' 'efficacy of chloroquine and hydroxychloroquine for the treatment of COVID-19 by determining ' 'the prevalence of COVID-19 in malaria pandemic and non-pandemic nations. We sought evidence ' 'to support or refute the hypothesis that these drugs could show efficacy in the treatment of ' 'COVID-19. MATERIALS AND METHODS: We reviewed in vitro studies, in vivo studies, original ' 'studies, clinical trials, and consensus reports, that were conducted to evaluate the ' 'antiviral activities of chloroquine and hydroxychloroquine. The studies on “COVID-19 and its ' 'allied treatment were found from World Health Organization (WHO), ISI-Web of Science, PubMed, ' 'EMBASE, Scopus, Google Scholar, and clinical trial registries. The search was based on ' 'keywords: antiviral drugs, chloroquine, hydroxychloroquine, COVID-19, COVID-19 treatment ' 'modalities, and coronavirus. In addition, we analyzed the prevalence of COVID-19 in malaria ' 'pandemic and non-pandemic countries. The review and analyses were performed on March 28, ' '2020. RESULTS: For this study, we identified a total of 09 published articles: 03 clinical ' 'trials with sample size 150; 03 in vitro studies and 03 expert consensus reports. These ' 'studies were all suggestive that chloroquine and hydroxychloroquine can successfully treat ' 'COVID-19 infections. We found that COVID-19 infections are highly pandemic in countries where ' 'malaria is least pandemic and are least pandemic in nations where malaria is highly pandemic. ' 'CONCLUSIONS: Chloroquine and hydroxychloroquine have antiviral characteristics in vitro. The ' 'findings support the hypothesis that these drugs have efficacy in the treatment of COVID-19. ' 'People are currently using these drugs for malaria. It is reasonable, given the hypothetical ' 'benefit of these two drugs, that they are now being tested in clinical trials to assess their ' 'effectiveness to combat this global health crisis.', 'container-title': 'European Review for Medical and Pharmacological Sciences', 'DOI': '10.26355/eurrev_202004_21038', 'ISSN': '1128-3602, 2284-0729', 'issue': '8', 'medium': 'JB', 'page': '4539-4547', 'page-first': '4539', 'publisher': 'Verduci Editore s.r.l.', 'publisher-place': 'IT', 'title': 'Efficacy of chloroquine and hydroxychloroquine in the treatment of COVID-19', 'URL': 'https://doi.org/10.26355/eurrev_202004_21038', 'volume': '24'}
Loading..
Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
  or use drag and drop   
Submit