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Structures and functions of coronavirus replication–transcription complexes and their relevance for SARS-CoV-2 drug design

Malone et al., Nature Reviews Molecular Cell Biology, doi:10.1038/s41580-021-00432-z
Nov 2021  
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Review of the structures and functions of coronavirus replication–transcription complexes, particularly focusing on their relevance for SARS-CoV-2 drug design. Authors discuss the molecular mechanisms of SARS-CoV-2's RNA synthesis, including the roles of various viral proteins in this process. They highlight the complexity of the coronavirus RNA-synthesizing machinery, outlining the mechanisms and regulation of RNA translation, replication, and transcription. Authors also examine the composition of the replication and transcription complexes, emphasizing their potential as targets for antiviral therapy.
Gérard, Wu, Zhou show significantly increased risk of acute kidney injury with remdesivir.
Malone et al., 25 Nov 2021, peer-reviewed, 4 authors. Contact:
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Structures and functions of coronavirus replication–transcription complexes and their relevance for SARS-CoV-2 drug design
Brandon Malone, Nadya Urakova, Eric J Snijder, Elizabeth A Campbell
Nature Reviews Molecular Cell Biology, doi:10.1038/s41580-021-00432-z
genome that has mRNA polarity and, when released from viral particles, can be used directly by host ribosomes to produce viral proteins.
Author contributions The authors contributed equally to all aspects of the article. Competing interests E.A.C has received funding from Gilead Sciences to fund research on remdesivir's incorporation into the RNAdependent RNA polymerase. The other authors declare no competing interests. Peer review information Nature Reviews Molecular Cell Biology thanks Hauke Hillen, Kenneth Johnson and Yi Shi for their contribution to the peer review of this work. Publisher's note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
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