Effect of the povidone iodine, hypertonic alkaline solution and saline nasal lavage on nasopharyngeal viral load in COVID-19

{ 'institution': [{'name': 'Authorea, Inc.'}], 'indexed': { 'date-parts': [[2022, 10, 27]], 'date-time': '2022-10-27T05:09:14Z', 'timestamp': 1666847354285}, 'posted': {'date-parts': [[2022, 10, 26]]}, 'group-title': 'Preprints', 'reference-count': 0, 'publisher': 'Authorea, Inc.', 'content-domain': {'domain': [], 'crossmark-restriction': False}, 'accepted': {'date-parts': [[2022, 10, 26]]}, 'abstract': '<jats:p id="p1">Objective: The causative virus of COVID-19 is SARS-CoV-2. The aim of the\n' 'present study was to invastigate the in vivo virucidal activity of nasal\n' 'irrigation with saline, nasal irrigation with Povidone-iodine (PVP-I)\n' '1%, nasal irrigation with hypertonic alkaline and nasal irrigation with\n' 'PVP-I 1% against SARS CoV- 2. Design: The present study was a\n' 'prospective randomized clinical trial. Setting: A multicenter study\n' 'involving tertiary care centers. Participants: The study included adult\n' 'outpatients whose qualitative SARS-CoV-2 RT-PCR tests in nasopharyngeal\n' 'swabs were positive. One hundred twenty patients divided into four equal\n' 'groups. Standard COVID-19 treatment was given to group 1 (n=30), nasal\n' 'irrigation containing isotonic solution was added to patients’ treatment\n' 'in group 2 (n=30), nasal irrigation containing 1% PVP solution was\n' 'added to patients’ treatment in group 3(n=30), and nasal irrigation\n' 'containing 1% PVP solution and nasal irrigation containing hypertonic\n' 'alkaline solution was added to patients’ treatment in group 4 (n=30).\n' 'Main outcome measures: On the first day of diagnosis (day 0),\n' 'nasopharyngeal swab samples were taken, on the 3rd and 5th days the\n' 'nasopharyngeal viral load reduction in quantitative RT-PCR tests were\n' 'calculated. Results: Between the 0-3rd Day and 0-5th days, the\n' 'nasopharyngeal viral load reduction was significant in all groups\n' '(p&lt; .05). In paired comparisons of groups, the nasopharyngeal\n' 'viral load decrease in group 4 in first 3 days was significantly lower\n' 'than all groups (p &lt; .05). The nasopharyngeal viral load\n' 'degrease in groups 3 and 4 in the first 5 days were significantly lower\n' 'than group 1 (p &lt; .05). Conclussion: This study was reveal\n' 'that the use of hypertonic alkaline nasal irrigation together with 1%\n' 'povidone-iodine was more effective in reducing viral load in the early\n' 'period. The decreased nasopharyngeal viral load may reduce the carriage\n' 'of infectious SARS-CoV-2 in patients. Our results suggest that 1%\n' 'povidone-iodine and hypertonic alkaline nasal irrigation may be\n' 'promising modality to prevent the COVID-19 epidemic.</jats:p>', 'DOI': '10.22541/au.166675335.56566797/v1', 'type': 'posted-content', 'created': { 'date-parts': [[2022, 10, 26]], 'date-time': '2022-10-26T03:02:41Z', 'timestamp': 1666753361000}, 'source': 'Crossref', 'is-referenced-by-count': 0, 'title': 'EFFECT OF THE POVIDONE IODINE, HYPERTONIC ALKALINE SOLUTION AND SALINE NASAL LAVAGE ON ' 'NASOPHARYNGEAL VIRAL LOAD IN COVID-19', 'prefix': '10.22541', 'author': [ { 'ORCID': 'http://orcid.org/0000-0002-8620-4375', 'authenticated-orcid': True, 'given': 'Aysegul', 'family': 'Karaaltin', 'sequence': 'first', 'affiliation': [{'name': 'Istanbul University'}]}, { 'given': 'ozgur', 'family': 'yigit', 'sequence': 'additional', 'affiliation': [{'name': 'istanbul education and research hospital'}]}, { 'given': 'dogan', 'family': 'cakan', 'sequence': 'additional', 'affiliation': [{'name': 'Istanbul University-Cerrahpasa'}]}, { 'given': 'özer', 'family': 'akgül', 'sequence': 'additional', 'affiliation': [{'name': 'Istanbul Aydin Universitesi'}]}, { 'given': 'Enes', 'family': 'Yiğit', 'sequence': 'additional', 'affiliation': [{'name': 'Istanbul Teaching and Research Hospital'}]}, { 'given': 'yetkin zeki', 'family': 'yılmaz', 'sequence': 'additional', 'affiliation': [{'name': 'İstanbul Üniversitesi-Cerrahpaşa'}]}, { 'given': 'Kays Burak', 'family': 'Çakır', 'sequence': 'additional', 'affiliation': [{'name': 'Istanbul Universitesi-Cerrahpasa'}]}, { 'given': 'gamze', 'family': 'çiftçi', 'sequence': 'additional', 'affiliation': [{'name': 'İstanbul Üniversitesi-Cerrahpaşa'}]}, { 'given': 'Nihal', 'family': 'Seden', 'sequence': 'additional', 'affiliation': [{'name': 'Istanbul Teaching and Research Hospital'}]}, { 'given': 'abdurrahman', 'family': 'çağlıyan', 'sequence': 'additional', 'affiliation': [{'name': 'Istanbul Teaching and Research Hospital'}]}, { 'given': 'Efe', 'family': 'Can', 'sequence': 'additional', 'affiliation': [{'name': 'Istanbul Teaching and Research Hospital'}]}, { 'given': 'özgür', 'family': 'dikme', 'sequence': 'additional', 'affiliation': [{'name': 'Istanbul Education Research Hospital'}]}, { 'given': 'yalçın', 'family': 'hacıoğlu', 'sequence': 'additional', 'affiliation': [{'name': 'Istanbul Teaching and Research Hospital'}]}, { 'given': 'ilker inanç', 'family': 'balkan', 'sequence': 'additional', 'affiliation': [{'name': 'İstanbul Üniversitesi-Cerrahpaşa'}]}, { 'given': 'özgün', 'family': 'enver', 'sequence': 'additional', 'affiliation': [{'name': 'Istanbul Aydin Universitesi'}]}, { 'given': 'Ahmet', 'family': 'Ozdogan', 'sequence': 'additional', 'affiliation': [{'name': 'Istanbul University Cerrahpasa Medical Faculty'}]}], 'member': '9829', 'container-title': [], 'original-title': [], 'deposited': { 'date-parts': [[2022, 10, 26]], 'date-time': '2022-10-26T03:02:42Z', 'timestamp': 1666753362000}, 'score': 1, 'resource': { 'primary': { 'URL': 'https://www.authorea.com/users/337860/articles/592062-effect-of-the-povidone-iodine-hypertonic-alkaline-solution-and-saline-nasal-lavage-on-nasopharyngeal-viral-load-in-covid-19?commit=bcb03d2ad8d86742ebd473271b70f5ab7211094d'}}, 'subtitle': [], 'short-title': [], 'issued': {'date-parts': [[2022, 10, 26]]}, 'references-count': 0, 'URL': 'http://dx.doi.org/10.22541/au.166675335.56566797/v1', 'relation': {}, 'published': {'date-parts': [[2022, 10, 26]]}, 'subtype': 'preprint'}