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Effect of calcifediol treatment and best available therapy versus best available therapy on intensive care unit admission and mortality among patients hospitalized for COVID-19: A pilot randomized clinical study

Castillo et al., Journal of Steroid Biochemistry and Molecular Biology, 203, October 2020, doi:10.1016/j.jsbmb.2020.105751
Aug 2020  
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HCQ for COVID-19
1st treatment shown to reduce risk in March 2020
 
*, now known with p < 0.00000000001 from 422 studies, recognized in 42 countries.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
4,100+ studies for 60+ treatments. c19hcq.org
RCT on calcifediol (25-hydroxyvitamin D) treatment for hospitalized COVID-19 patients showing significantly reduced intensive care unit admissions. All patients received standard care including HCQ+AZ. Significantly lower ICU admission with the addition of calcifediol - adjusted odds ratio 0.03 [0.003-0.25]. No deaths for calcifediol (0/50), 2 deaths for SOC (2/26).
Study covers vitamin D and HCQ.
Castillo et al., 29 Aug 2020, peer-reviewed, 7 authors.
This PaperHCQAll
“Effect of calcifediol treatment and best available therapy versus best available therapy on intensive care unit admission and mortality among patients hospitalized for COVID-19: A pilot randomized clinical study”
Marta Entrenas Castillo, Luis Manuel Entrenas Costa, José Manuel Vaquero Barrios, Juan Francisco Alcalá Díaz, José López Miranda, Roger Bouillon, José Manuel Quesada Gomez
The Journal of Steroid Biochemistry and Molecular Biology, doi:10.1016/j.jsbmb.2020.105751
Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre -including this research content -immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
References
Andrukhov, Andrukhova, Hulan, Tang, Bantleon et al., Both 25-hydroxyvitamin-D3 and 1,25-dihydroxyvitamin-D3 reduces inflammatory response in human periodontal ligament cells, PLoS One, doi:10.1371/journal.pone.0090301
Avataneo, Manca, Cusato, De Nicolò, Lucchini et al., 25-hydroxyvitamin D concentrations are lower in patients with positive PCR for SARS-CoV-2, Nutrients, doi:10.3390/nu12051359
Bauchner, Fontanarosa, Randomized clinical trials and COVID-19: managing expectations, JAMA -J. Am. Med. Assoc, doi:10.1001/jama.2020.8115
Bellani, Laffey, Pham, Fan, Brochard et al., Epidemiology, patterns of care, and mortality for patients with acute respiratory distress syndrome in intensive care units in 50 countries, JAMA -J. Am. Med. Assoc, doi:10.1001/jama.2016.0291
Bouillon, Bikle, Vitamin D metabolism revised: fall of dogmas, J. Bone Miner. Res, doi:10.1002/jbmr.3884
Bouillon, Marcocci, Carmeliet, Bikle, White et al., Skeletal and extraskeletal actions of vitamin d: current evidence and outstanding questions, Endocr. Rev, doi:10.1210/er.2018-00126
Chen, Zhou, Dong, Qu, Gong et al., Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study, Lancet, doi:10.1016/S0140-6736(20)30211-7
De, Ministerio De Sanidad, Consumo Y Bienestar Social -Documentos Técnicos Para Profesionales -Coronavirus
Fan, Brodie, Slutsky, Acute respiratory distress syndrome, JAMA, doi:10.1001/jama.2017.21907
Geleris, Sun, Platt, Zucker, Baldwin et al., Observational study of hydroxychloroquine in hospitalized patients with COVID-19, N. Engl. J. Med, doi:10.1056/NEJMoa2012410
Grant, Boucher, Bhattoa, Lahore, Why vitamin D clinical trials should be based on 25-hydroxyvitamin D concentrations, J. Steroid Biochem. Mol. Biol, doi:10.1016/j.jsbmb.2017.08.009
Hansdottir, Monick, Hinde, Lovan, Look et al., Respiratory epithelial cells convert inactive vitamin d to its active form: potential effects on host defense, J. Immunol, doi:10.4049/jimmunol.181.10.7090
Heaney, Guidelines for optimizing design and analysis of clinical studies of nutrient effects, Nutr. Rev, doi:10.1111/nure.12090
Huang, Wang, Li, Ren, Zhao et al., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China, Lancet, doi:10.1016/S0140-6736(20)30183-5
Ilie, Stefanescu, Smith, The role of vitamin D in the prevention of coronavirus disease 2019 infection and mortality, Aging Clin. Exp. Res, doi:10.1007/s40520-020-01570-8
Jolliffe, Stefanidis, Wang, Kermani, Dimitrov et al., Vitamin D metabolism is dysregulated in Asthma and chronic obstructive pulmonary disease, Am. J. Respir. Crit. Care Med, doi:10.1164/rccm.201909-1867oc
Kong, Zhu, Shi, Liu, Chen et al., VDR attenuates acute lung injury by blocking Ang-2-Tie-2 pathway and reninangiotensin system, Mol. Endocrinol, doi:10.1210/me.2013-1146
Laird, Rhodes, Kenny, Vitamin, And inflammation: potential implications for severity of Covid-19, Ir. Med. J
Li, Rivers, Tan, Murray, Toner et al., Estimated demand for US hospital inpatient and intensive care unit beds for patients with COVID-19 based on comparisons with Wuhan and Guangzhou, China, JAMA Netw. Open, doi:10.1001/jamanetworkopen.2020.8297
Lim, Van Der Eerden, Laing, Boersma, Karalus et al., Defining community acquired pneumonia severity on presentation to hospital: an international derivation and validation study, Thorax, doi:10.1136/thorax.58.5.377
Mandell, Wunderink, Anzueto, Bartlett, Campbell et al., Infectious diseases society of America/American thoracic society consensus guidelines on the management of community-acquired pneumonia in adults, Clin. Infect. Dis, doi:10.1086/511159
Martineau, Forouhi, Vitamin D for COVID-19: a case to answer?, Lancet Diabetes Endocrinol, doi:10.1016/S2213-8587(20)30268-0
Martinez-Moreno, Herencia, De Oca, Muñoz-Castañeda, Rodríguez-Ortiz et al., Vitamin D modulates tissue factor and protease-activated receptor 2 expression in vascular smooth muscle cells, FASEB J, doi:10.1096/fj.15-272872
Mata-Granados, Luque De Castro, Gomez, Inappropriate serum levels of retinol, α-tocopherol, 25 hydroxyvitamin D3 and 24,25 dihydroxyvitamin D3 levels in healthy Spanish adults: simultaneous assessment by HPLC, Clin. Biochem, doi:10.1016/j.clinbiochem.2008.02.003
Mata-Granados, Vargas-Vasserot, Ferreiro-Vera, Luque De Castro, Pavón et al., Evaluation of vitamin D endocrine system (VDES) status and response to treatment of patients in intensive care units (ICUs) using an on-line SPE-LC-MS/MS method, J. Steroid Biochem. Mol. Biol, doi:10.1016/j.jsbmb.2010.03.078
Panagiotou, Tee, Ihsan, Athar, Marchitelli et al., Low serum 25-hydroxyvitamin D (25[OH]D) levels in patients hospitalised with COVID-19 are associated with greater disease severity, Clin. Endocrinol, doi:10.1111/cen.14276
Quesada-Gomez, Bouillon, Is calcifediol better than cholecalciferol for vitamin D supplementation?, Osteoporos. Int, doi:10.1007/s00198-018-4520-y
Quesada-Gomez, Entrenas-Castillo, Bouillon, Vitamin D receptor stimulation to reduce acute respiratory distress syndrome (ARDS) in patients with coronavirus SARS-CoV-2 infections: revised Ms SBMB 2020_166, J. Steroid Biochem. Mol. Biol, doi:10.1016/j.jsbmb.2020.105719
Rafique, Rejnmark, Heickendorff, Møller, OH)D 3 and 1.25(OH) 2 D 3 inhibits TNF-α expression in human monocyte derived macrophages, PLoS One, doi:10.1371/journal.pone.0215383
Ranieri, Rubenfeld, Thompson, Ferguson, Caldwell et al., Acute respiratory distress syndrome: the Berlin definition, JAMA -J. Am. Med. Assoc, doi:10.1001/jama.2012.5669
Recovery Collaborative Group, Horby, Lim, Emberson, Mafham et al., Dexamethasone in hospitalized patients with Covid-19 -preliminary report, N. Engl. J. Med, doi:10.1056/NEJMoa2021436
Russo, Carlucci, Cipriani, Ragno, Piemonte et al., Metabolic changes following 500 μg monthly administration of calcidiol: a study in normal females, Calcif. Tissue Int, doi:10.1007/s00223-011-9513-1
Schulz, Altman, Moher, Consort, Statement: Updated guidelines for reporting parallel group randomised trials, BMC Med, doi:10.1186/1741-7015-8-18
Shi, Liu, Fu, Xu, Wu et al., Vitamin D/VDR signaling attenuates lipopolysaccharide-induced acute lung injury by maintaining the integrity of the pulmonary epithelial barrier, Mol. Med. Rep, doi:10.3892/mmr.2015.4685
Shi, Liu, Fu, Xu, Wu et al., Vitamin D/VDR signaling attenuates lipopolysaccharide-induced acute lung injury by maintaining the integrity of the pulmonary epithelial barrier, Mol. Med. Rep, doi:10.3892/mmr.2015.4685
Simonnet, Chetboun, Poissy, Raverdy, Noulette et al., High prevalence of obesity in severe acute respiratory syndrome Coronavirus-2 (SARS-CoV-2) requiring invasive mechanical ventilation, Obesity, doi:10.1002/oby.22831
Viechtbauer, Smits, Kotz, Budé, Spigt et al., A simple formula for the calculation of sample size in pilot studies, J. Clin. Epidemiol, doi:10.1016/j.jclinepi.2015.04.014
Wu, Chen, Cai, Xia, Zhou et al., Risk factors associated with acute respiratory distress syndrome and death in patients with coronavirus disease 2019 Pneumonia in Wuhan, China, JAMA Intern. Med, doi:10.1001/jamainternmed.2020.0994
Xu, Shi, Wang, Zhang, Huang et al., Pathological findings of COVID-19 associated with acute respiratory distress syndrome, Lancet Respir. Med, doi:10.1016/S2213-2600(20)30076-X
Zheng, Yang, Hu, Li, Wang et al., Vitamin D attenuates lung injury via stimulating epithelial repair, reducing epithelial cell apoptosis and inhibits TGF-β induced epithelial to mesenchymal transition, Biochem. Pharmacol, doi:10.1016/j.bcp.2020.113955
Zhou, Yang, Wang, Hu, Zhang et al., A pneumonia outbreak associated with a new coronavirus of probable bat origin, Nature, doi:10.1038/s41586-020-2012-7
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Rep.', 'key': '10.1016/j.jsbmb.2020.105751_bib0065', 'volume': '13', 'year': '2016'}, { 'DOI': '10.1210/me.2013-1146', 'article-title': 'VDR attenuates acute lung injury by blocking Ang-2-Tie-2 pathway and ' 'renin-angiotensin system', 'author': 'Kong', 'doi-asserted-by': 'crossref', 'first-page': '2116', 'journal-title': 'Mol. Endocrinol.', 'key': '10.1016/j.jsbmb.2020.105751_bib0070', 'volume': '27', 'year': '2013'}, { 'DOI': '10.1016/j.bcp.2020.113955', 'article-title': 'Vitamin D attenuates lung injury via stimulating epithelial repair, ' 'reducing epithelial cell apoptosis and inhibits TGF-β induced ' 'epithelial to mesenchymal transition', 'author': 'Zheng', 'doi-asserted-by': 'crossref', 'journal-title': 'Biochem. Pharmacol.', 'key': '10.1016/j.jsbmb.2020.105751_bib0075', 'volume': '177', 'year': '2020'}, { 'DOI': '10.1096/fj.15-272872', 'article-title': 'Vitamin D modulates tissue factor and protease-activated receptor 2 ' 'expression in vascular smooth muscle cells', 'author': 'Martinez-Moreno', 'doi-asserted-by': 'crossref', 'first-page': '1367', 'journal-title': 'FASEB J.', 'key': '10.1016/j.jsbmb.2020.105751_bib0080', 'volume': '30', 'year': '2016'}, { 'article-title': 'Vitamin D. And inflammation: potential implications for severity of ' 'Covid-19', 'author': 'Laird', 'journal-title': 'Ir. Med. J.', 'key': '10.1016/j.jsbmb.2020.105751_bib0085', 'volume': '113', 'year': '2020'}, { 'DOI': '10.1007/s40520-020-01570-8', 'article-title': 'The role of vitamin D in the prevention of coronavirus disease 2019 ' 'infection and mortality', 'author': 'Ilie', 'doi-asserted-by': 'crossref', 'first-page': '1195', 'journal-title': 'Aging Clin. Exp. Res.', 'key': '10.1016/j.jsbmb.2020.105751_bib0090', 'volume': '32', 'year': '2020'}, { 'DOI': '10.3390/nu12051359', 'article-title': '25-hydroxyvitamin D concentrations are lower in patients with positive ' 'PCR for SARS-CoV-2', 'author': 'D’avolio', 'doi-asserted-by': 'crossref', 'journal-title': 'Nutrients', 'key': '10.1016/j.jsbmb.2020.105751_bib0095', 'volume': '12', 'year': '2020'}, { 'article-title': 'Low serum 25-hydroxyvitamin D (25[OH]D) levels in patients hospitalised ' 'with COVID-19 are associated with greater disease severity', 'author': 'Panagiotou', 'journal-title': 'Clin. Endocrinol. (Oxf).', 'key': '10.1016/j.jsbmb.2020.105751_bib0100', 'year': '2020'}, { 'DOI': '10.1016/j.clinbiochem.2008.02.003', 'article-title': 'Inappropriate serum levels of retinol, α-tocopherol, 25 hydroxyvitamin ' 'D3 and 24,25 dihydroxyvitamin D3 levels in healthy Spanish adults: ' 'simultaneous assessment by HPLC', 'author': 'Mata-Granados', 'doi-asserted-by': 'crossref', 'first-page': '676', 'journal-title': 'Clin. Biochem.', 'key': '10.1016/j.jsbmb.2020.105751_bib0105', 'volume': '41', 'year': '2008'}, { 'DOI': '10.1016/j.jsbmb.2010.03.078', 'article-title': 'Evaluation of vitamin D endocrine system (VDES) status and response to ' 'treatment of patients in intensive care units (ICUs) using an on-line ' 'SPE-LC-MS/MS method', 'author': 'Mata-Granados', 'doi-asserted-by': 'crossref', 'first-page': '452', 'journal-title': 'J. Steroid Biochem. Mol. Biol.', 'key': '10.1016/j.jsbmb.2020.105751_bib0110', 'volume': '121', 'year': '2010'}, { 'key': '10.1016/j.jsbmb.2020.105751_bib0115', 'series-title': 'Gobierno De España, Ministerio De Sanidad, Consumo Y Bienestar Social - ' 'Documentos Técnicos Para Profesionales - Coronavirus', 'year': '2020'}, { 'key': '10.1016/j.jsbmb.2020.105751_bib0120', 'unstructured': 'Tratamientos disponibles sujetos a condiciones especiales de acceso para ' 'el manejo de la infección respiratoria por SARS-CoV-2 - Agencia Española ' 'de Medicamentos y Productos Sanitarios, (n.d.). ' 'https://www.aemps.gob.es/la-aemps/ultima-informacion-de-la-aemps-acerca-del-covid-19/tratamientos-disponibles-para-el-manejo-de-la-infeccion-respiratoria-por-sars-cov-2/?lang=en ' '(accessed June 22, 2020).'}, { 'DOI': '10.1136/thorax.58.5.377', 'article-title': 'Defining community acquired pneumonia severity on presentation to ' 'hospital: an international derivation and validation study', 'author': 'Lim', 'doi-asserted-by': 'crossref', 'first-page': '377', 'journal-title': 'Thorax', 'key': '10.1016/j.jsbmb.2020.105751_bib0125', 'volume': '58', 'year': '2003'}, { 'key': '10.1016/j.jsbmb.2020.105751_bib0130', 'unstructured': 'In Vitro Antiviral Activity and Projection of Optimized Dosing Design of ' 'Hydroxychloroquine for the Treatment of Severe Acute Respiratory ' 'Syndrome Coronavirus 2 (SARS-CoV-2) - PubMed, (n.d.). ' 'https://pubmed.ncbi.nlm.nih.gov/32150618/ (accessed June 23, 2020).'}, { 'DOI': '10.1086/511159', 'article-title': 'Infectious diseases society of America/American thoracic society ' 'consensus guidelines on the management of community-acquired pneumonia ' 'in adults', 'author': 'Mandell', 'doi-asserted-by': 'crossref', 'first-page': 'S27', 'journal-title': 'Clin. Infect. Dis.', 'key': '10.1016/j.jsbmb.2020.105751_bib0135', 'volume': '44', 'year': '2007'}, { 'DOI': '10.1016/j.jclinepi.2015.04.014', 'article-title': 'A simple formula for the calculation of sample size in pilot studies', 'author': 'Viechtbauer', 'doi-asserted-by': 'crossref', 'first-page': '1375', 'journal-title': 'J. Clin. Epidemiol.', 'key': '10.1016/j.jsbmb.2020.105751_bib0140', 'volume': '68', 'year': '2015'}, { 'DOI': '10.1007/s00223-011-9513-1', 'article-title': 'Metabolic changes following 500 μg monthly administration of calcidiol: ' 'a study in normal females', 'author': 'Russo', 'doi-asserted-by': 'crossref', 'first-page': '252', 'journal-title': 'Calcif. Tissue Int.', 'key': '10.1016/j.jsbmb.2020.105751_bib0145', 'volume': '89', 'year': '2011'}, { 'key': '10.1016/j.jsbmb.2020.105751_bib0150', 'unstructured': 'Laboratory testing for 2019 novel coronavirus (2019-nCoV) in suspected ' 'human cases, (n.d.). ' 'https://www.who.int/publications/i/item/10665-331501 (accessed June 23, ' '2020).'}, { 'DOI': '10.1186/1741-7015-8-18', 'article-title': 'CONSORT 2010 Statement: Updated guidelines for reporting parallel group ' 'randomised trials', 'author': 'Schulz', 'doi-asserted-by': 'crossref', 'journal-title': 'BMC Med.', 'key': '10.1016/j.jsbmb.2020.105751_bib0155', 'volume': '8', 'year': '2010'}, { 'DOI': '10.1056/NEJMoa2012410', 'article-title': 'Observational study of hydroxychloroquine in hospitalized patients with ' 'COVID-19', 'author': 'Geleris', 'doi-asserted-by': 'crossref', 'first-page': '2411', 'journal-title': 'N. Engl. J. Med.', 'key': '10.1016/j.jsbmb.2020.105751_bib0160', 'volume': '382', 'year': '2020'}, { 'DOI': '10.1210/er.2018-00126', 'article-title': 'Skeletal and extraskeletal actions of vitamin d: current evidence and ' 'outstanding questions', 'author': 'Bouillon', 'doi-asserted-by': 'crossref', 'first-page': '1109', 'journal-title': 'Endocr. Rev.', 'key': '10.1016/j.jsbmb.2020.105751_bib0165', 'volume': '40', 'year': '2019'}, { 'DOI': '10.4049/jimmunol.181.10.7090', 'article-title': 'Respiratory epithelial cells convert inactive vitamin d to its active ' 'form: potential effects on host defense', 'author': 'Hansdottir', 'doi-asserted-by': 'crossref', 'first-page': '7090', 'journal-title': 'J. Immunol.', 'key': '10.1016/j.jsbmb.2020.105751_bib0170', 'volume': '181', 'year': '2008'}, { 'DOI': '10.1371/journal.pone.0215383', 'article-title': '25(OH)D 3 and 1.25(OH) 2 D 3 inhibits TNF-α expression in human ' 'monocyte derived macrophages', 'author': 'Rafique', 'doi-asserted-by': 'crossref', 'journal-title': 'PLoS One', 'key': '10.1016/j.jsbmb.2020.105751_bib0175', 'volume': '14', 'year': '2019'}, { 'DOI': '10.1371/journal.pone.0090301', 'article-title': 'Both 25-hydroxyvitamin-D3 and 1,25-dihydroxyvitamin- D3 reduces ' 'inflammatory response in human periodontal ligament cells', 'author': 'Andrukhov', 'doi-asserted-by': 'crossref', 'first-page': 'e90301', 'journal-title': 'PLoS One', 'key': '10.1016/j.jsbmb.2020.105751_bib0180', 'volume': '9', 'year': '2014'}, { 'DOI': '10.1002/oby.22831', 'article-title': 'High prevalence of obesity in severe acute respiratory syndrome ' 'Coronavirus-2 (SARS-CoV-2) requiring invasive mechanical ventilation', 'author': 'Simonnet', 'doi-asserted-by': 'crossref', 'first-page': '1195', 'journal-title': 'Obesity.', 'key': '10.1016/j.jsbmb.2020.105751_bib0185', 'volume': '28', 'year': '2020'}, { 'DOI': '10.1016/S2213-8587(20)30268-0', 'article-title': 'Vitamin D for COVID-19: a case to answer?', 'author': 'Martineau', 'doi-asserted-by': 'crossref', 'journal-title': 'Lancet Diabetes Endocrinol.', 'key': '10.1016/j.jsbmb.2020.105751_bib0190', 'year': '2020'}, { 'DOI': '10.1111/nure.12090', 'article-title': 'Guidelines for optimizing design and analysis of clinical studies of ' 'nutrient effects', 'author': 'Heaney', 'doi-asserted-by': 'crossref', 'first-page': '48', 'journal-title': 'Nutr. Rev.', 'key': '10.1016/j.jsbmb.2020.105751_bib0195', 'volume': '72', 'year': '2014'}, { 'DOI': '10.1016/j.jsbmb.2017.08.009', 'article-title': 'Why vitamin D clinical trials should be based on 25-hydroxyvitamin D ' 'concentrations', 'author': 'Grant', 'doi-asserted-by': 'crossref', 'first-page': '266', 'journal-title': 'J. Steroid Biochem. Mol. Biol.', 'key': '10.1016/j.jsbmb.2020.105751_bib0200', 'volume': '177', 'year': '2018'}, { 'DOI': '10.1002/jbmr.3884', 'article-title': 'Vitamin D metabolism revised: fall of dogmas', 'author': 'Bouillon', 'doi-asserted-by': 'crossref', 'first-page': '1985', 'journal-title': 'J. Bone Miner. Res.', 'key': '10.1016/j.jsbmb.2020.105751_bib0205', 'volume': '34', 'year': '2019'}, { 'DOI': '10.1164/rccm.201909-1867OC', 'article-title': 'Vitamin D metabolism is dysregulated in Asthma and chronic obstructive ' 'pulmonary disease', 'author': 'Jolliffe', 'doi-asserted-by': 'crossref', 'journal-title': 'Am. J. Respir. Crit. Care Med.', 'key': '10.1016/j.jsbmb.2020.105751_bib0210', 'year': '2020'}, { 'DOI': '10.1007/s00198-018-4520-y', 'article-title': 'Is calcifediol better than cholecalciferol for vitamin D ' 'supplementation?', 'author': 'Quesada-Gomez', 'doi-asserted-by': 'crossref', 'first-page': '1697', 'journal-title': 'Osteoporos. Int.', 'key': '10.1016/j.jsbmb.2020.105751_bib0215', 'volume': '29', 'year': '2018'}, { 'article-title': 'Dexamethasone in hospitalized patients with Covid-19 - preliminary ' 'report', 'author': 'RECOVERY Collaborative Group', 'journal-title': 'N. Engl. J. Med.', 'key': '10.1016/j.jsbmb.2020.105751_bib0220', 'year': '2020'}, { 'key': '10.1016/j.jsbmb.2020.105751_bib0225', 'unstructured': 'Corticosteroids (including dexamethasone). NIH website. Updated July 17, ' '2020. Accessed August, 2020. ' 'https://www.covid19treatmentguidelines.nih.gov/dexamethasone/.'}], 'reference-count': 45, 'references-count': 45, 'relation': {}, 'resource': {'primary': {'URL': 'https://linkinghub.elsevier.com/retrieve/pii/S0960076020302764'}}, 'score': 1, 'short-title': [], 'source': 'Crossref', 'subject': [ 'Cell Biology', 'Clinical Biochemistry', 'Endocrinology', 'Molecular Biology', 'Molecular Medicine', 'Biochemistry', 'Endocrinology, Diabetes and Metabolism'], 'subtitle': [], 'title': '“Effect of calcifediol treatment and best available therapy versus best available therapy on ' 'intensive care unit admission and mortality among patients hospitalized for COVID-19: A pilot ' 'randomized clinical study”', 'type': 'journal-article', 'update-policy': 'http://dx.doi.org/10.1016/elsevier_cm_policy', 'volume': '203'}
Late treatment
is less effective
Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
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