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All Studies   Meta Analysis       

Colchicine for COVID-19: real-time meta analysis of 56 studies

Covid Analysis
Nov 2024  
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Colchicine for COVID-19
5th treatment shown to reduce risk in September 2020, now with p = 0.00000031 from 56 studies.
No treatment is 100% effective. Protocols combine treatments.
5,000+ studies for 104 treatments. c19early.org
Statistically significant lower risk is seen for mortality, ICU admission, hospitalization, and recovery. 26 studies from 26 independent teams in 15 countries show significant improvements.
Meta analysis using the most serious outcome reported shows 27% [18‑36%] lower risk. Results are similar for higher quality and peer-reviewed studies and worse for Randomized Controlled Trials. Clinical outcomes suggest benefit while viral and case outcomes do not, consistent with an intervention that aids the immune system or recovery but may have limited antiviral effects. Early treatment is more effective than late treatment.
Results are robust — in exclusion sensitivity analysis 22 of 56 studies must be excluded to avoid finding statistically significant efficacy in pooled analysis.
RCT results are less favorable, however they are dominated by the very late stage RECOVERY RCT which is not generalizable to earlier usage.
No treatment or intervention is 100% effective. All practical, effective, and safe means should be used based on risk/benefit analysis. Multiple treatments are typically used in combination, and other treatments are more effective.
All data to reproduce this paper and sources are in the appendix. 10 other meta analyses show significant improvements with colchicine for mortality1-8, oxygen therapy8, hospitalization9, and severity10.
10 meta analyses show significant improvements with colchicine for mortality1-8, oxygen therapy8, hospitalization9, and severity10.
Covid Analysis et al., Nov 2024, preprint, 1 author.
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Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
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