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A Preventive Study on Hydroxychloroquine Prophylaxis against COVID-19 in Health Care Workers at a Tertiary Care Center in North India

Bhandari et al., International Journal of Medicine and Public Health, doi:10.5530/ijmedph.2021.1.4
Feb 2021  
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HCQ for COVID-19
1st treatment shown to reduce risk in March 2020, now with p < 0.00000000001 from 419 studies, recognized in 46 countries.
No treatment is 100% effective. Protocols combine treatments.
5,100+ studies for 110 treatments. c19hcq.org
Retrospective 4,239 healthcare workers using HCQ prophylaxis showing no mortality, 8 mild symptomatic cases, and 85 asymptomatic cases, with the cases occuring mostly in the first week.
Bhandari et al., 28 Feb 2021, India, peer-reviewed, 10 authors.
This PaperHCQAll
A Preventive Study on Hydroxychloroquine Prophylaxis against COVID-19 in Health Care Workers at a Tertiary Care Center in North India
Sudhir Bhandari, Dr Govind Rankawat, Shivam Priydarshi, Nachiketa Vyas, Ajeet Singh, Raman Sharma, Vishal Gupta, Shrikant Sharma, Nidhi Gupta, Monisha Singhal, Govind Rankawat
doi:10.5530/ijmedph.2021.1.4
Background: The menace of COVID-19 has put a huge burden on health care system predisposing health care workers engaged in management to COVID-19 infections. The nonavailability of effective drug against COVID-19 warrants extra cover as prophylactic therapy for health care workers, especially against transmission from asymptomatic patients. Hydroxychloroquine (HCQ) for prophylaxis of COVID-19 had been advocated by some researchers. Hence, in this project, evaluation of HCQ as preventive strategy for healthcare workers against COVID-19 infection was studied. Materials and Methods: HCQ was prescribed as a prophylactic therapy as per the advisory of National Task Force of Indian Council of Medical Research, India. The data regarding consumption profile, COVID-19 infection and adverse drug reaction profile of HCQ in healthcare workers was collected. Results: Record of 4,239 health workers with hydroxychloroquine consumed was available till date. 139 subjects were dropped out of study as they did not consume the HCQ tablets. 93 heath workers (2.19%) were infected with COVID-19 infection but in early weeks of prophylactic therapy and were asymptomatic. A few of them (08 patients) had mild symptomatic manifestation with RT-PCR reported positive for SARS-CoV-2. No mortality was reported as among healthcare workers, engaged in management of COVID-19 patients at the tertiary care institute in Jaipur, India. HCQ prophylaxis in standard doses produced predominantly gastrointestinal side effects in 20 subject and headache in 10 health workers. Conclusion: The present study showed that HCQ prophylaxis is safe and effective in standard doses against COVID-19 infection. The frontline workers engaged in management of COVID-19 may be given HCQ prophylaxis as an extra cover. However, it's broadening usage as preventive strategy, in general for people especially in cardiovascular incidences; require enhanced research and further validation.
Ethical approval This study proved by ethical and research committee of SMS Medical College and Hospital, Jaipur, India. Author contributions S. Bhandari, S. Priydarshi and N. Vyas formulated the research questions, designed the study and developed the preliminary search strategy. G. Rankawat, S. Priydarshi and N. Vyas collected and analyzed data and drafted the manuscript. S. Bhandari, A. Singh, R. Sharma, V. Gupta, S. Sharma, N. Gupta and M. Singhal conducted the quality assessment and review the manuscript. All authors critically reviewed the manuscript for relevant intellectual content. All authors have read and approved the final version of the manuscript. CONFLICT OF INTEREST All authors report no potential conflicts. All authors have submitted the ICMJE Form for Disclosure of Potential. ABBREVIATIONS
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