Conv. Plasma
Nigella Sativa

All HCQ studies
Meta analysis
study COVID-19 treatment researchHCQHCQ (more..)
Melatonin Meta
Metformin Meta
Azvudine Meta
Bromhexine Meta Molnupiravir Meta
Budesonide Meta
Colchicine Meta
Conv. Plasma Meta Nigella Sativa Meta
Curcumin Meta Nitazoxanide Meta
Famotidine Meta Paxlovid Meta
Favipiravir Meta Quercetin Meta
Fluvoxamine Meta Remdesivir Meta
Hydroxychlor.. Meta Thermotherapy Meta
Ivermectin Meta

All Studies   Meta Analysis    Recent:   

A Preventive Study on Hydroxychloroquine Prophylaxis against COVID-19 in Health Care Workers at a Tertiary Care Center in North India

Bhandari et al., International Journal of Medicine and Public Health, doi:10.5530/ijmedph.2021.1.4
Feb 2021  
  Source   PDF   All Studies   Meta AnalysisMeta
HCQ for COVID-19
1st treatment shown to reduce risk in March 2020
*, now known with p < 0.00000000001 from 422 studies, recognized in 42 countries.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
4,000+ studies for 60+ treatments.
Retrospective 4,239 healthcare workers using HCQ prophylaxis showing no mortality, 8 mild symptomatic cases, and 85 asymptomatic cases, with the cases occuring mostly in the first week.
Bhandari et al., 28 Feb 2021, India, peer-reviewed, 10 authors.
This PaperHCQAll
A Preventive Study on Hydroxychloroquine Prophylaxis against COVID-19 in Health Care Workers at a Tertiary Care Center in North India
Sudhir Bhandari, Dr Govind Rankawat, Shivam Priydarshi, Nachiketa Vyas, Ajeet Singh, Raman Sharma, Vishal Gupta, Shrikant Sharma, Nidhi Gupta, Monisha Singhal, Govind Rankawat
Background: The menace of COVID-19 has put a huge burden on health care system predisposing health care workers engaged in management to COVID-19 infections. The nonavailability of effective drug against COVID-19 warrants extra cover as prophylactic therapy for health care workers, especially against transmission from asymptomatic patients. Hydroxychloroquine (HCQ) for prophylaxis of COVID-19 had been advocated by some researchers. Hence, in this project, evaluation of HCQ as preventive strategy for healthcare workers against COVID-19 infection was studied. Materials and Methods: HCQ was prescribed as a prophylactic therapy as per the advisory of National Task Force of Indian Council of Medical Research, India. The data regarding consumption profile, COVID-19 infection and adverse drug reaction profile of HCQ in healthcare workers was collected. Results: Record of 4,239 health workers with hydroxychloroquine consumed was available till date. 139 subjects were dropped out of study as they did not consume the HCQ tablets. 93 heath workers (2.19%) were infected with COVID-19 infection but in early weeks of prophylactic therapy and were asymptomatic. A few of them (08 patients) had mild symptomatic manifestation with RT-PCR reported positive for SARS-CoV-2. No mortality was reported as among healthcare workers, engaged in management of COVID-19 patients at the tertiary care institute in Jaipur, India. HCQ prophylaxis in standard doses produced predominantly gastrointestinal side effects in 20 subject and headache in 10 health workers. Conclusion: The present study showed that HCQ prophylaxis is safe and effective in standard doses against COVID-19 infection. The frontline workers engaged in management of COVID-19 may be given HCQ prophylaxis as an extra cover. However, it's broadening usage as preventive strategy, in general for people especially in cardiovascular incidences; require enhanced research and further validation.
Ethical approval This study proved by ethical and research committee of SMS Medical College and Hospital, Jaipur, India. Author contributions S. Bhandari, S. Priydarshi and N. Vyas formulated the research questions, designed the study and developed the preliminary search strategy. G. Rankawat, S. Priydarshi and N. Vyas collected and analyzed data and drafted the manuscript. S. Bhandari, A. Singh, R. Sharma, V. Gupta, S. Sharma, N. Gupta and M. Singhal conducted the quality assessment and review the manuscript. All authors critically reviewed the manuscript for relevant intellectual content. All authors have read and approved the final version of the manuscript. CONFLICT OF INTEREST All authors report no potential conflicts. All authors have submitted the ICMJE Form for Disclosure of Potential. ABBREVIATIONS
Bhandari, Rankawat, Priydarshi, Vyas, Singh et al., A Preventive Study on Hydroxychloroquine Prophylaxis against COVID-19 in Health Care Workers at a Tertiary Care Center in North India
Biot, Daher, Chavain, Fandeur, Khalife et al., Design and synthesis of hydroxyferroquine derivatives with antimalarial and antiviral activities, J Med Chem
Biot, Daher, Chavain, Fandeur, Khalife et al., Design and synthesis of hydroxyferroquine derivatives with antimalarial and antiviral activities, J Med Chem
Chatterjee, Anand, Singh, Rasaily, Singh et al., Healthcare workers and SARS-CoV-2 infection in India: A case-control investigation in the time of COVID-19, Indian J Med Res, doi:10.4103/ijmr.IJMR_2234_20
Chen, Xiong, Bao, Shi, Convalescent plasma as a potential therapy for COVID-19, Lancet Infect Dis, doi:10.1016/S1473-3099(20)30141-9
Conti, Ronconi, Caraffa, Induction of pro-inflammatory cytokines (IL-1 and IL-6) and lung inflammation by Coronavirus-19 (COVI-19 or SARS-CoV-2): Anti-inflammatory strategies, J Biol Regul Homeost Agents, doi:10.23812/CONTI-E
Devaux, Rolain, Colson, Raoult, New insights on the antiviral effects of chloroquine against coronavirus: What to expect for COVID-19?
Fox, Mechanism of action of hydroxychloroquine as an antirheumatic drug, Seminars in Arthritis and Rheumatism, doi:10.1016/s0049-0172(10)80012-5
Hashem, Alghamdi, Algaissi, Alshehri, Bukhari et al., Therapeutic use of chloroquine and hydroxychloroquine in COVID-19 and other viral infections: A narrative review, Travel Med Infect Dis, doi:17.10.1016/j.tmaid.2020.101735
Huang, Wang, Li, Ren, Zhao et al., Clinical Features of patients infected with 2019 novel coronavirus in Wuhan, China, Lancet
Lee, Son, Peck, Can post-exposure prophylaxis for COVID-19 be considered as an outbreak response strategy in long-term care hospitals?, Int J Antimicrob Agents, doi:10.1016/j.ijantimicag.2020.105988
Liu, Cao, Xu, Wang, Zhang et al., Hydroxychloroquine, a less toxic derivative of chloroquine, is effective in inhibiting SARS-CoV-2 infection in vitro, Cell Discov
Liu, Li, Liu, Longitudinal characteristics of lymphocyte responses and cytokine profiles in the peripheral blood of SARS-CoV-2 infected patients, Med Rxiv, doi:10.1101/2020.02.16.20023671
Ma, Chloroquine analogues in drug discovery: New directions of uses, mechanisms of actions and toxic manifestations from malaria to multifarious diseases, J Antimicrob Chemother, doi:10.1093/jac/dkv018
Maa, Targeting endosomal acidification by chloroquine analogs as a promising strategy for the treatment of emerging viral diseases, Pharmacol Res Perspect
Me´garbane, Chloroquine and hydroxychloroquine to treat COVID-19: between hope and caution, Clin Toxicol
Perricone, Triggianese, Bartoloni, The anti-viral facet of anti-rheumatic drugs: lessons from COVID-19, J Autoimmun, doi:10.1016/j.jaut.2020.102468
Popert, Choloroquine: A review, Rheumatology
Principi, Esposito, Chloroquine or hydroxychloroquine for prophylaxis of COVID-19, Lancet Infect Dis, doi:10.1016/S1473-3099(20)30296-6
Rainsford, Parke, Clifford-Rashotte, Kean, Therapy and pharmacological properties of hydroxychloroquine and chloroquine in treatment of systemic lupus erythematosus, rheumatoid arthritis and related diseases, Inflammopharmacology, doi:10.1007/s10787-015-0239-y
Traebert, Dumotier, Meister, Hoffmann, Dominguez-Estevez et al., Inhibition of hERG K+ currents by antimalarial drugs in stably transfected HEK293 cells, Eur J Pharmacol
Yao, Ye, Zhang, Cui, Huang et al., In vitro antiviral activity and projection of optimized dosing design of hydroxychloroquine for the treatment of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Clinical Infectious Diseases
Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
  or use drag and drop