Effectiveness of different treatment regimens on patients with COVID-19, hospitalized in Sanandaj hospitals: a retrospective cohort study

{ 'indexed': {'date-parts': [[2023, 1, 17]], 'date-time': '2023-01-17T06:04:56Z', 'timestamp': 1673935496146}, 'reference-count': 36, 'publisher': 'Springer Science and Business Media LLC', 'issue': '1', 'license': [ { 'start': { 'date-parts': [[2023, 1, 16]], 'date-time': '2023-01-16T00:00:00Z', 'timestamp': 1673827200000}, 'content-version': 'tdm', 'delay-in-days': 0, 'URL': 'https://creativecommons.org/licenses/by/4.0'}, { 'start': { 'date-parts': [[2023, 1, 16]], 'date-time': '2023-01-16T00:00:00Z', 'timestamp': 1673827200000}, 'content-version': 'vor', 'delay-in-days': 0, 'URL': 'https://creativecommons.org/licenses/by/4.0'}], 'content-domain': {'domain': ['link.springer.com'], 'crossmark-restriction': False}, 'abstract': '<jats:title>Abstract</jats:title><jats:sec>\n' ' <jats:title>Objectives</jats:title>\n' ' <jats:p>Different drugs have different effects on the prognosis of patients ' 'with COVID-19. This study aimed to evaluate the effect of different drug regimens on patients ' 'with COVID-19, hospitalized in Sanandaj city.</jats:p>\n' ' </jats:sec><jats:sec>\n' ' <jats:title>Methods</jats:title>\n' ' <jats:p>In this retrospective cohort study, 660 patients with COVID-19, ' 'hospitalized in the Tohid, Kowsar and Besat hospitals located Sanandaj (Kurdistan Province, ' 'Iran) were studied from February 2020 to February 2021 with clinical symptoms and positive ' 'test results.</jats:p>\n' ' </jats:sec><jats:sec>\n' ' <jats:title>Results</jats:title>\n' ' <jats:p>The results of multivariate regression analysis showed the days of ' 'hospitalization for patients who had received the drug regimen 2 (Interferons ' '(ReciGen/Ziphron) or Interferon Vectra (lopinavir/ritonavir)) was 1.92 times higher than ' 'those who had received the drug regimen 1 (hydroxychloroquine group or a combination of ' 'chloroquine and azithromycin) while a significant association was observed (OR\u2009=\u2009' '1.92, 95% CI: 1.16–3.16, <jats:italic>P</jats:italic>\u2009=\u20090.011). Also, the ' 'hospitalization in ICU was longer in patients treated by the drug regimen 2 (Interferons ' '(ReciGen/Ziphron) or Interferon Vectra (lopinavir/ritonavir)) (OR\u2009=\u20094.63, 95% CI: ' '1.80–11.82, <jats:italic>P</jats:italic>\u2009=\u20090.001), however, drug regimens did not ' 'show a significant effect on mortality and use of ventilator in patients ' '(<jats:italic>P</jats:italic>\u2009&gt;\u20090.05).</jats:p>\n' ' </jats:sec><jats:sec>\n' ' <jats:title>Conclusion</jats:title>\n' ' <jats:p>The study results showed the drug regimens 2 and 5 increased the days ' 'of hospitalization and hospitalization in ICU, respectively, while the other drug regimens ' 'had no significant effect on mortality and use a ventilator in the studied patients and none ' 'of the drug regimens had an effect on reducing mortality compared to other ones.</jats:p>\n' ' </jats:sec>', 'DOI': '10.1186/s40545-023-00511-w', 'type': 'journal-article', 'created': {'date-parts': [[2023, 1, 16]], 'date-time': '2023-01-16T12:03:04Z', 'timestamp': 1673870584000}, 'update-policy': 'http://dx.doi.org/10.1007/springer_crossmark_policy', 'source': 'Crossref', 'is-referenced-by-count': 0, 'title': 'Effectiveness of different treatment regimens on patients with COVID-19, hospitalized in ' 'Sanandaj hospitals: a retrospective cohort study', 'prefix': '10.1186', 'volume': '16', 'author': [ {'given': 'Jalal', 'family': 'Asadi', 'sequence': 'first', 'affiliation': []}, {'given': 'Mohammad Aziz', 'family': 'Rasouli', 'sequence': 'additional', 'affiliation': []}, {'given': 'Ebrahim', 'family': 'Ghaderi', 'sequence': 'additional', 'affiliation': []}, {'given': 'Daem', 'family': 'Roshani', 'sequence': 'additional', 'affiliation': []}, {'given': 'Behzad', 'family': 'Mohsenpour', 'sequence': 'additional', 'affiliation': []}, {'given': 'Yousef', 'family': 'Moradi', 'sequence': 'additional', 'affiliation': []}, {'given': 'Ghobad', 'family': 'Moradi', 'sequence': 'additional', 'affiliation': []}], 'member': '297', 'published-online': {'date-parts': [[2023, 1, 16]]}, 'reference': [ { 'issue': '3', 'key': '511_CR1', 'first-page': '10650', 'volume': '20', 'author': 'N Wani', 'year': '2021', 'unstructured': 'Wani N. 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(All patients provided ' 'written informed consents. The relevant guidelines and regulations performed ' 'all methods.)', 'order': 2, 'name': 'Ethics', 'group': {'name': 'EthicsHeading', 'label': 'Ethics approval and consent to participate'}}, { 'value': 'Not applicable.', 'order': 3, 'name': 'Ethics', 'group': {'name': 'EthicsHeading', 'label': 'Consent for publication'}}, { 'value': 'The authors declare that they have no competing interests.', 'order': 4, 'name': 'Ethics', 'group': {'name': 'EthicsHeading', 'label': 'Competing interests'}}], 'article-number': '4'}