Early Multidrug Outpatient Treatment of SARS-CoV-2 Infection (COVID-19) and Reduced Mortality Among Nursing Home Residents
Review of studies on treatment of COVID-19 for nursing home residents, concluding that there is a large >60% mortality risk reduction associated with multidrug treatment using two or more intracellular anti-infectives (HCQ and either AZM or DOXY) combined with other agents including corticosteroids, anti-thrombotics, and nutraceuticals. Authors note there is also recent focus on ivermectin and favorable evidence for bromhexine.
Alexander et al., 1 Feb 2021, preprint, 11 authors.
Abstract: medRxiv preprint doi: https://doi.org/10.1101/2021.01.28.21250706; this version posted February 1, 2021. The copyright holder for this preprint
(which was not certified by peer review) is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity.
All rights reserved. No reuse allowed without permission.
Early Multidrug Outpatient Treatment of SARS-CoV-2 Infection (COVID-19) and
Reduced Mortality Among Nursing Home Residents
Paul E Alexander MSc, PhD, Robin Armstrong, MD, George Fareed, MD, Kulvinder K.
Gill, MD, John Lotus, BS, Ramin Oskoui, MD, Chad Prodromos, MD, Harvey A. Risch,
MD, PhD, Howard C Tenenbaum, DDS, PhD, Craig M. Wax, DO, Peter A. McCullough,
MD, MPH
Paul E Alexander MSc PhD, McMaster University and GUIDE Research Methods
Group, Hamilton, Ontario, Canada elias98_99@yahoo.com
Robin Armstrong, MD, The Resort at Texas City Nursing Home, Texas City, TX, USA
robarmstr@hotmail.com
George Fareed, MD, Pioneers Health Center, Brawley, CA, USA gfareed@gmail.com
Kulvinder K. Gill, MD, Concerned Ontario Doctors, Toronto, Ontario, Canada
John Lotus, BS, The Foundation for Orthopaedics and Regenerative Medicine
(FOReM), Chicago, IL, USA jlotus21@uchicago.edu
Ramin Oskoui, MD, CEO, Foxhall Cardiology, PC, Washington, DC
oskouimd@gmail.com
Chad Podromomos, MD, The Foundation for Orthopaedics and Regenerative Medicine
(FOReM), Chicago, IL USA chadprodromos@gmail.com
Harvey A. Risch, MD, PhD, Yale School of Public Health, New Haven, CT USA
harvey.risch@yale.edu
Howard C. Tenenbaum DDS, Dip. Perio., PhD, FRCD(C) Centre for Advanced Dental
Research and Care, Mount Sinai Hospital, and Faculties of Medicine and Dentistry,
University of Toronto, Toronto, ON, Canada
howard.tenenbaum@sinaihealth.ca
Craig M. Wax, DO, Family Physician, Independent Physicians for Patient
Independence, New Jersey, AAPS board of Directors
physician1@comcast.net
Peter A. McCullough, MD, MPH, Baylor University Medical Center, Baylor Heart and
Vascular Institute, Baylor Jack and Jane Hamilton Heart and Vascular Hospital, Dallas,
TX, USA peteramccullough@gmail.com
Address for Correspondence
1
NOTE: This preprint reports new research that has not been certified by peer review and should not be used to guide clinical practice.
medRxiv preprint doi: https://doi.org/10.1101/2021.01.28.21250706; this version posted February 1, 2021. The copyright holder for this preprint
(which was not certified by peer review) is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity.
All rights reserved. No reuse allowed without permission.
Paul E Alexander MSc PhD, McMaster University and GUIDE Research Methods
Group, Hamilton, Ontario, Canada elias98_99@yahoo.com
Word Count 5546
Funding source(s): none related
Conflict of interest statement for author and co-authors: nothing to disclose
Authors had access to the data and wrote the manuscript
Views and opinions expressed are only of the authors listed and not of their
organizations of employment
Running head: Early Multidrug Regimen for COVID-19 in Nursing Homes
Acknowledgement: We thank Mr. Erik Sass, editor-in-chief of The Economic Standard
for his oversight and input.
Key words: SARS-CoV-2; COVID-19; nursing home; elderly; hospitalization; mortality;
ambulatory treatment; anti-infective; anti-inflammatory; antiviral; corticosteroid;
antiplatelet agent; anticoagulant
2
medRxiv preprint doi: https://doi.org/10.1101/2021.01.28.21250706; this version posted February..
Please send us corrections, updates, or comments. Vaccines and
treatments are complementary. All practical, effective, and safe means should
be used based on risk/benefit analysis. No treatment, vaccine, or intervention
is 100% available and effective for all current and future variants. We do not
provide medical advice. Before taking any medication, consult a qualified
physician who can provide personalized advice and details of risks and
benefits based on your medical history and situation.
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