Abstract: medRxiv preprint doi: https://doi.org/10.1101/2021.01.28.21250706; this version posted February 1, 2021. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission. Early Multidrug Outpatient Treatment of SARS-CoV-2 Infection (COVID-19) and Reduced Mortality Among Nursing Home Residents Paul E Alexander MSc, PhD, Robin Armstrong, MD, George Fareed, MD, Kulvinder K. Gill, MD, John Lotus, BS, Ramin Oskoui, MD, Chad Prodromos, MD, Harvey A. Risch, MD, PhD, Howard C Tenenbaum, DDS, PhD, Craig M. Wax, DO, Peter A. McCullough, MD, MPH Paul E Alexander MSc PhD, McMaster University and GUIDE Research Methods Group, Hamilton, Ontario, Canada elias98_99@yahoo.com Robin Armstrong, MD, The Resort at Texas City Nursing Home, Texas City, TX, USA robarmstr@hotmail.com George Fareed, MD, Pioneers Health Center, Brawley, CA, USA gfareed@gmail.com Kulvinder K. Gill, MD, Concerned Ontario Doctors, Toronto, Ontario, Canada John Lotus, BS, The Foundation for Orthopaedics and Regenerative Medicine (FOReM), Chicago, IL, USA jlotus21@uchicago.edu Ramin Oskoui, MD, CEO, Foxhall Cardiology, PC, Washington, DC oskouimd@gmail.com Chad Podromomos, MD, The Foundation for Orthopaedics and Regenerative Medicine (FOReM), Chicago, IL USA chadprodromos@gmail.com Harvey A. Risch, MD, PhD, Yale School of Public Health, New Haven, CT USA harvey.risch@yale.edu Howard C. Tenenbaum DDS, Dip. Perio., PhD, FRCD(C) Centre for Advanced Dental Research and Care, Mount Sinai Hospital, and Faculties of Medicine and Dentistry, University of Toronto, Toronto, ON, Canada howard.tenenbaum@sinaihealth.ca Craig M. Wax, DO, Family Physician, Independent Physicians for Patient Independence, New Jersey, AAPS board of Directors physician1@comcast.net Peter A. McCullough, MD, MPH, Baylor University Medical Center, Baylor Heart and Vascular Institute, Baylor Jack and Jane Hamilton Heart and Vascular Hospital, Dallas, TX, USA peteramccullough@gmail.com Address for Correspondence 1 NOTE: This preprint reports new research that has not been certified by peer review and should not be used to guide clinical practice. medRxiv preprint doi: https://doi.org/10.1101/2021.01.28.21250706; this version posted February 1, 2021. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission. Paul E Alexander MSc PhD, McMaster University and GUIDE Research Methods Group, Hamilton, Ontario, Canada elias98_99@yahoo.com Word Count 5546 Funding source(s): none related Conflict of interest statement for author and co-authors: nothing to disclose Authors had access to the data and wrote the manuscript Views and opinions expressed are only of the authors listed and not of their organizations of employment Running head: Early Multidrug Regimen for COVID-19 in Nursing Homes Acknowledgement: We thank Mr. Erik Sass, editor-in-chief of The Economic Standard for his oversight and input. Key words: SARS-CoV-2; COVID-19; nursing home; elderly; hospitalization; mortality; ambulatory treatment; anti-infective; anti-inflammatory; antiviral; corticosteroid; antiplatelet agent; anticoagulant 2 medRxiv preprint doi: https://doi.org/10.1101/2021.01.28.21250706; this version posted February..