Hydroxychloroquine / azithromycin in COVID-19: The association between time to treatment and case fatality rate
Roberto Alfonso Accinelli, Grisel Jesús Ynga-Meléndez, Juan Alonso León-Abarca, Lidia Marianella López, Juan Carlos Madrid-Cisneros, Juan Diego Mendoza-Saldaña
Travel Medicine and Infectious Disease, doi:10.1016/j.tmaid.2021.102163
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References
Andreani, Bideau, Duflot, Jardot, Rolland et al., In vitro testing of combined hydroxychloroquine and azithromycin on SARS-CoV-2 shows synergistic effect, Microb Pathog
Apaydın, Çınar, Cihan-Üstündağ, Small-molecule antiviral agents in ongoing clinical trials for COVID-19, Curr Drug Targets
Arshad, Pertinez, Box, Tatham, Rajoli et al., Prioritization of anti-SARS-Cov-2 drug repurposing opportunities based on plasma and target site concentrations derived from their established human pharmacokinetics, J o u r n a l P r e -p r o o f Oct
Callender, Curran, Bates, Mairesse, Weigandt et al., The Impact of Pre-existing Comorbidities and Therapeutic Interventions on COVID-19, Front Immunol
Chen, Zhang, Fu, Feng, Zhang et al., Efficacy and safety of chloroquine or hydroxychloroquine in moderate type of COVID-19: a prospective open-label randomized controlled study, MedRxiv
Chirinos, Vf, Heresi-Dávila, Hernandez, Málaga et al., -p r o o f
Derwand, Scholz, Zelenko, COVID-19 Outpatients -Early Risk-Stratified Treatment with Zinc Plus Low Dose Hydroxychloroquine and Azithromycin: A Retrospective Case Series Study, Int J Antimicrob Agents
Ebina-Shibuya, Namkoong, Horita, Kato, Hara et al., Hydroxychloroquine and chloroquine for treatment of coronavirus disease 19 (COVID-19): a systematic review and meta-analysis of randomized and nonrandomized controlled trials, J Thorac Dis
Fang, Zhang, Xie, Lin, Ying et al., Sensitivity of Chest CT for COVID-19: Comparison to RT-PCR, Radiology
Fantini, Chahinian, Yahi, Synergistic antiviral effect of hydroxychloroquine and azithromycin in combination against SARS-CoV-2: What molecular dynamics studies of virus-host interactions reveal, Int J Antimicrob Agents
Fantini, Scala, Chahinian, Yahi, Structural and molecular modelling studies reveal a new mechanism of action of chloroquine and hydroxychloroquine against SARS-CoV-2 infection, Int J Antimicrob Agents
Fonseca, De, Sousa, Wolkoff, Moreira et al., Risk of hospitalization for Covid-19 outpatients treated with various drug regimens in Brazil: Comparative analysis, Travel Med Infect Dis
Gautret, Lagier, Parola, Meddeb, Mailhe et al., Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial, Int J Antimicrob Agents
Glaumann, Ahlberg, Comparison of different autophagic vacuoles with regard to ultrastructure, enzymatic composition, and degradation capacity-Formation of crinosomes, Exp Mol Pathol
Gordon, Jang, Bouhaddou, Xu, Obernier et al., A SARS-CoV-2 protein interaction map reveals targets for drug repurposing, Nature
Guisado-Vasco, Valderas-Ortega, Santacruz, O U R N A L P R E -P R O O F González-Cortijo, Sotres-Fernández et al., Clinical characteristics and outcomes among hospitalized adults with severe COVID-19 admitted to a tertiary medical center and receiving antiviral, antimalarials, glucocorticoids, or immunomodulation with tocilizumab or cyclosporine: A retrospective observational study (COQUIMA cohort), EClinicalMedicine
Guo, Mi, Nie, Seropositivity rate and diagnostic accuracy of serological tests in 2019-nCoV cases: a pooled analysis of individual studies, Eur Rev Med Pharmacol Sci
Guérin, Lévy, Thomas, Lardenois, Lacrosse et al., Azithromycin and Hydroxychloroquine Accelerate Recovery of Outpatients with Mild / Moderate, Asian J Med Heal
Heras, Garibaldi, Boix, Valero, Castillo et al., CO VID-19 mortality risk factors in older people in a long-term care center, Eur Geriatr Med
Hiba, Chowers, Levi-Vinograd, Rubinovitch, Leibovici et al., Benefit of early treatment with oseltamivir in hospitalized patients with documented 2009 influenza A (H1N1): retrospective cohort study, J Antimicrob Chemother
Hong, Jang, Hur, Lee, Kim et al., Early hydroxychloroquine administration for rapid severe acute respiratory syndrome coronavirus 2 eradication, Infect Chemother
Ip, Ahn, Zhou, Goy, Hansen et al., Hydroxychloroquine in the treatment of outpatients with mildly symptomatic COVID-19: a multi-center observational study, BMC infect dis
Keyaerts, Vijgen, Maes, Neyts, Van Ranst, In vitro inhibition of severe acute respiratory syndrome coronavirus by chloroquine, Biochem Biophys Res Commun
Kumar, Early versus late oseltamivir treatment in severely ill patients with 2009 pandemic influenza A (H1N1): speed is life, J Antimicrob Chemother
Lenze, Mattar, Zorumski, Stevens, Schweiger et al., u r n a l P r e -p r o o f priming protease of SARS-CoV-2 in human cells, and identification of putative modulators, Redox Biol
Li, Moore, Vasilieva, Sui, Wong et al., Angiotensin-converting enzyme J o u r n a l P r e -p r o o f 2 is a functional receptor for the SARS coronavirus, Nature
Lin, Ferguson, White, Wang, Vessella et al., Prostate-localized and androgen-regulated expression of the membrane-bound serine protease TMPRSS2, Cancer Res
Liu, Cao, Xu, Wang, Zhang et al., Hydroxychloroquine, a less toxic derivative of chloroquine, is effective in inhibiting SARS-CoV-2 infection in vitro, Cell Discov
Mallucci, Effect of chloroquine on lysosomes and on growth of mouse hepatitis virus (MHV-3), Virology
Mccullough, Kelly, Ruocco, Lerma, Tumlin et al., Pathophysiological basis and rationale for early outpatient treatment of SARS-CoV-2 (COVID-19) infection, Am J Med
Meftahi, Jangravi, Sahraei, Bahari, The possible pathophysiology mechanism of cytokine storm in elderly adults with COVID-19 infection: the contribution of "inflame-aging, Inflamm Res
Million, Lagier, Gautret, Colson, Fournier et al., Early treatment of COVID-19 J o u r n a l P r e -p r o o f patients with hydroxychloroquine and azithromycin: A retrospective analysis of 1061 cases in Marseille, France, Travel Med Infect Dis
Mokhtari, Mohraz, Gouya, Tabar, Tabrizi et al., Clinical J o u r n a l P r e -p r o o f outcomes of patients with mild COVID-19 following treatment with hydroxychloroquine in an outpatient setting, Int Immunopharmacol
Nandy, Salunke, Pathak, Pandey, Doctor et al., Coronavirus disease (COVID-19): A systematic review and meta-analysis to evaluate the impact of various comorbidities on serious events, Diabetes Metab Syndr
Niessen, Gibson, Baines, Barker, Yang et al., Sputum TNF markers are increased in neutrophilic and severe asthma and are reduced by azithromycin treatment, Allergy
Ohkuma, Poole, Fluorescence probe measurement of the intralysosomal pH in living cells and the perturbation of pH by various agents, Proc Natl Acad Sci
Oscanoa, Romero-Ortuno, Carvajal, Savarino, A pharmacological perspective of chloroquine in SARS-CoV-2 infection: An old drug for the fight against a new coronavirus?, Int J Antimicrob Agents
Padhy, Mohanty, Das, Meher, Therapeutic potential of ivermectin as add on treatment in COVID 19: A systematic review and meta-analysis: Ivermectin in COVID-19: A meta-analysis, J Pharm Pharm Sci
Pastick, Okafor, Wang, Lofgren, Skipper et al., Review: Hydroxychloroquine and Chloroquine for Treatment of SARS-CoV-2 (COVID-19), Open Forum Infect Dis
Pedersen, Ho, SARS-CoV-2: a storm is raging, J Clin Invest
Prodromos, Rumschlag, Hydroxychloroquine is effective, and consistently so when provided early, for COVID-19: a systematic review, New Microbes New Infect
Ritter, Kreis, Louwen, Yuan, Obesity and COVID-19: Molecular Mechanisms Linking Both Pandemics, Int J Mol Sci
Rodríguez, Díaz, Martín-Loeches, Sandiumenge, Canadell et al., Impact of early oseltamivir treatment on outcome in critically ill patients with 2009 pandemic influenza A, J Antimicrob Chemother
Savarino, Boelaert, Cassone, Majori, Cauda, Effects of chloroquine on viral infections: an old drug against today's diseases?, Lancet Infect Dis
Savarino, Buonavoglia, Norelli, Trani, Di et al., Potential therapies for coronaviruses, Expert Opin Ther Pat
Spn, Sopemi, Sopehe, Sociedad Peruana de Medicina Interna. COMUNICADO CONJUTNO SPMI
Su, Ling, Ma, Tao, Miao et al., Efficacy of early hydroxychloroquine treatment in preventing COVID-19 pneumonia aggravation, the experience from Shanghai, China, Biosci trends
Sulaiman, Mohana, Alawdah, Mahmoud, Hassanein et al., The effect of early hydroxychloroquine-based therapy in COVID-19 patients in ambulatory care settings: a nationwide prospective cohort study
Tardif, Bouabdallaoui, Allier, Gaudet, Shah et al., Colchicine for community-treated patients with COVID-19 (COLCORONA): a phase 3, randomised, double-blinded, adaptive, placebo-controlled, multicentre trial, Lancet Respir Med
Touret, Gilles, Barral, Nougairède, Van Helden et al., In vitro screening of a FDA approved chemical library reveals potential inhibitors of SARS-CoV-2 replication, Sci Rep
Vincent, Bergeron, Benjannet, Erickson, Rollin et al., Chloroquine is a potent inhibitor of SARS coronavirus infection and spread, Virol J
Wang, Cao, Zhang, Yang, Liu et al., Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro, Cell Res
Worldometer, COVID-19 Coronavirus pandemic
Xie, Wang, Liao, Marley, Wu et al., Epidemiologic, clinical, and laboratory findings of the COVID-19 in the current pandemic: systematic review and meta-analysis, BMC Infect Dis
Yang, Zheng, Gou, Pu, Chen et al., Prevalence of comorbidities and its effects in patients infected with SARS-CoV-2: a systematic review and meta-analysis, Int J Infect Dis
Younis, Zareef, Hassan, Bitar, Eid et al., Hydroxychloroquine in COVID-19 Patients: Pros and Cons, Front Pharmacol
Zarychanski, Stuart, Kumar, Doucette, Elliott et al., Correlates of severe disease in patients with 2009 pandemic influenza (H1N1) virus infection, Can Med Assoc J
